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Peptide record

TPDB08973

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08973
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb AI4AVP dbAMP 3.0 APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RGGGLCYCRRRFCVCVGR
Physicochemical Analysis
C84H141N33O20S4
ANDEQHIKMPSTW
R
2061.49
9.95
5
0
5
+5
0.64
-0.022
53.89
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1740
84.40
5
Residue Composition
number
0
A
5
R
0
N
0
D
4
C
0
E
0
Q
4
G
0
H
0
I
1
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 4 E: 0 Q: 0 G: 4 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 2
Chemical Descriptors
18
C84H141N33O20S4
2061.49
9.95
+5
0.64
-0.022
Evidence Records 6 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
More active against a mprF mutant strain ( Peschel et al., 2001 ). Active against C. albicans ( Cho Y et al., 1998 ).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
More active against a mprF mutant strain ( Peschel et al., 2001 ). Active against C. albicans ( Cho Y et al., 1998 ).
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
More active against a mprF mutant strain ( Peschel et al., 2001 ). Active against C. albicans ( Cho Y et al., 1998 ).
Evidence 4 Activity

Activity

Antiviral

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
More active against a mprF mutant strain ( Peschel et al., 2001 ). Active against C. albicans ( Cho Y et al., 1998 ).
Evidence 5 Activity

Activity

51.70% Hemolysis
Toxicity
294.3 µg/mL
Hemolytic Cytotoxic
51.70% Hemolysis | 294.3 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of cell selectivity, physiological stability and endotoxin neutralization capabilities of ?-helix-based peptide amphiphiles. | Biomaterials | 2015
Evidence 6 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.