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Peptide record

TPDB08972

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB08972
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb dbAMP 3.0 AI4AVP DRAVP 2.0 ToxinPred 3.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GFLSILKKVLPKVMAHMK
Physicochemical Analysis
C96H166N24O20S2
RNDCEQTWY
K
2040.64
11.00
5
0
10
+4
1.90
0.617
124.44
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
1
H
1
I
3
L
4
K
2
M
1
F
1
P
1
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 1 L: 3 K: 4 M: 2 F: 1 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
18
C96H166N24O20S2
2040.64
11.00
+4
1.90
0.617
Evidence Records 30 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.8 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against B. subtilis (MIC 0.8 uM), S. aureus MRSA (MIC 6.8-25 uM), E. coli (MIC 2-25 uM), and P. aeruginosa (MIC 18.5 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
6.8-25 µM

Target

Staphylococcus aureus MRSA

Source & Reference

dbAMP DRAMP

Other

Active against B. subtilis (MIC 0.8 uM), S. aureus MRSA (MIC 6.8-25 uM), E. coli (MIC 2-25 uM), and P. aeruginosa (MIC 18.5 uM). The peptide also exhibits mast c
Evidence 3 Activity

Activity

MIC
Antibacterial
2-25 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Active against B. subtilis (MIC 0.8 uM), S. aureus MRSA (MIC 6.8-25 uM), E. coli (MIC 2-25 uM), and P. aeruginosa (MIC 18.5 uM). The peptide also exhibits mast cell degranulating activ
Evidence 4 Activity

Activity

MIC
Antibacterial
18.5 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

inst B. subtilis (MIC 0.8 uM), S. aureus MRSA (MIC 6.8-25 uM), E. coli (MIC 2-25 uM), and P. aeruginosa (MIC 18.5 uM). The peptide also exhibits mast cell degranulating activity. Also, the peptide was found
Evidence 5 Activity

Activity

MIC
Antifungal
0.8 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against B. subtilis (MIC 0.8 uM), S. aureus MRSA (MIC 6.8-25 uM), E. coli (MIC 2-25 uM), and P. aeruginosa (MIC 18.5 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
6.8-25 µM

Target

Staphylococcus aureus MRSA

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against B. subtilis (MIC 0.8 uM), S. aureus MRSA (MIC 6.8-25 uM), E. coli (MIC 2-25 uM), and P. aeruginosa (MIC 18.5 uM). The peptide also exhibits mast c
Evidence 7 Activity

Activity

MIC
Antifungal
2-25 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against B. subtilis (MIC 0.8 uM), S. aureus MRSA (MIC 6.8-25 uM), E. coli (MIC 2-25 uM), and P. aeruginosa (MIC 18.5 uM). The peptide also exhibits mast cell degranulating activ
Evidence 8 Activity

Activity

MIC
Antifungal
18.5 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

inst B. subtilis (MIC 0.8 uM), S. aureus MRSA (MIC 6.8-25 uM), E. coli (MIC 2-25 uM), and P. aeruginosa (MIC 18.5 uM). The peptide also exhibits mast cell degranulating activity. Also, the peptide was found
Evidence 9 Activity

Activity

MIC
Antiparasitic
0.8 µM

Target

B. subtilis

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against B. subtilis (MIC 0.8 uM), S. aureus MRSA (MIC 6.8-25 uM), E. coli (MIC 2-25 uM), and P. aeruginosa (MIC 18.5 uM).
Evidence 10 Activity

Activity

MIC
Antiparasitic
6.8-25 µM

Target

Staphylococcus aureus MRSA

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against B. subtilis (MIC 0.8 uM), S. aureus MRSA (MIC 6.8-25 uM), E. coli (MIC 2-25 uM), and P. aeruginosa (MIC 18.5 uM). The peptide also exhibits mast c
Evidence 11 Activity

Activity

MIC
Antiparasitic
2-25 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against B. subtilis (MIC 0.8 uM), S. aureus MRSA (MIC 6.8-25 uM), E. coli (MIC 2-25 uM), and P. aeruginosa (MIC 18.5 uM). The peptide also exhibits mast cell degranulating activ
Evidence 12 Activity

Activity

MIC
Antiparasitic
18.5 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP 3.0 DRAMP

Other

inst B. subtilis (MIC 0.8 uM), S. aureus MRSA (MIC 6.8-25 uM), E. coli (MIC 2-25 uM), and P. aeruginosa (MIC 18.5 uM). The peptide also exhibits mast cell degranulating activity. Also, the peptide was found
Evidence 13 Activity

Activity

MIC
Antiviral
0.8 µM

Target

B. subtilis

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
Active against B. subtilis (MIC 0.8 uM), S. aureus MRSA (MIC 6.8-25 uM), E. coli (MIC 2-25 uM), and P. aeruginosa (MIC 18.5 uM).
Evidence 14 Activity

Activity

MIC
Antiviral
6.8-25 µM

Target

Staphylococcus aureus MRSA

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Active against B. subtilis (MIC 0.8 uM), S. aureus MRSA (MIC 6.8-25 uM), E. coli (MIC 2-25 uM), and P. aeruginosa (MIC 18.5 uM). The peptide also exhibits mast c
Evidence 15 Activity

Activity

MIC
Antiviral
2-25 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Active against B. subtilis (MIC 0.8 uM), S. aureus MRSA (MIC 6.8-25 uM), E. coli (MIC 2-25 uM), and P. aeruginosa (MIC 18.5 uM). The peptide also exhibits mast cell degranulating activ
Evidence 16 Activity

Activity

MIC
Antiviral
18.5 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

inst B. subtilis (MIC 0.8 uM), S. aureus MRSA (MIC 6.8-25 uM), E. coli (MIC 2-25 uM), and P. aeruginosa (MIC 18.5 uM). The peptide also exhibits mast cell degranulating activity. Also, the peptide was found
Evidence 17 Activity

Activity

50% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >100 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Evidence 18 Activity

Activity

EC50
Toxicity
19.4 µM
Cytotoxic
EC50 | 19.4 | µM | target cell: Rat mast cells

Target

Rat mast cells

Source & Reference

NA
DBAASP
Melectin: a novel antimicrobial peptide from the venom of the cleptoparasitic bee Melecta albifrons | Chembiochem | 2008
Evidence 19 Activity

Activity

50% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effect of hydrocarbon stapling on the properties of ?-helical antimicrobial peptides isolated from the venom of hymenoptera. | Amino Acids | 2012
Evidence 20 Activity

Activity

50% Cell death
Toxicity
7.75 µM
Cytotoxic
50% Cell death | 7.75 | µM | target cell: CEM-SS cells

Target

CEM-SS cells

Source & Reference

NA
DBAASP
Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. | Antimicrob Agents Chemother | 2010
Evidence 21 Activity

Activity

IC50
Toxicity
21.53±1.59 µM
Cytotoxic
IC50 | 21.53±1.59 | µM | target cell: Human pancreas epithelial cells HPNE

Target

Human pancreas epithelial cells HPNE

Source & Reference

NA
DBAASP
Discovery of anticancer peptides from natural and generated sequences using deep learning. | Int J Biol Macromol | 2025
Evidence 22 Activity

Activity

IC50
Toxicity
>50 µM
Cytotoxic
IC50 | >50 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Discovery of anticancer peptides from natural and generated sequences using deep learning. | Int J Biol Macromol | 2025
Evidence 23 Activity

Activity

IC50
Toxicity
22.80±1.74 µM
Cytotoxic
IC50 | 22.80±1.74 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Discovery of anticancer peptides from natural and generated sequences using deep learning. | Int J Biol Macromol | 2025
Evidence 24 Activity

Activity

IC50
Toxicity
>50 µM
Cytotoxic
IC50 | >50 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Discovery of anticancer peptides from natural and generated sequences using deep learning. | Int J Biol Macromol | 2025
Evidence 25 Activity

Activity

<10% Hemolysis
Toxicity
62.5 µM
Hemolytic Cytotoxic
<10% Hemolysis | 62.5 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Discovery of anticancer peptides from natural and generated sequences using deep learning. | Int J Biol Macromol | 2025
Evidence 26 Activity

Activity

50% Hemolysis
Toxicity
190 µM
Hemolytic Cytotoxic
50% Hemolysis | 190 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Discovery of anticancer peptides from natural and generated sequences using deep learning. | Int J Biol Macromol | 2025
Evidence 27 Activity

Activity

50% Hemolysis
Toxicity
16.4 µM
Hemolytic Cytotoxic
50% Hemolysis | 16.4 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Melectin MAPs: the influence of dendrimerization on antimicrobial and hemolytic activity. | Amino Acids | 2010
Evidence 28 Activity

Activity

50% Hemolysis
Toxicity
18.5 µM
Hemolytic Cytotoxic
50% Hemolysis | 18.5 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Melectin MAPs: the influence of dendrimerization on antimicrobial and hemolytic activity. | Amino Acids | 2010
Evidence 29 Activity

Activity

50% Hemolysis
Toxicity
6.8 µM
Hemolytic Cytotoxic
50% Hemolysis | 6.8 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Melectin MAPs: the influence of dendrimerization on antimicrobial and hemolytic activity. | Amino Acids | 2010
Evidence 30 Activity

Activity

LC50
Toxicity
100 µM
Hemolytic
Hemolytic_activity: [Ref.18942691]LC50>100 µM against rat red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Chembiochem. 2008 Nov 24 9(17):2815-2821.