Back to search

Peptide record

TPDB08971

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB08971
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic PD_Hemolysis ToxinPred 3.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GFLGSLLKTGLKVGSNLL
Physicochemical Analysis
C84H145N21O23
ARDCEQHIMPWY
L
1817.20
10.60
2
0
8
+2
-1.58
0.811
146.11
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
4
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
0
Q
4
G
0
H
0
I
6
L
2
K
0
M
1
F
0
P
2
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 0 L: 6 K: 2 M: 0 F: 1 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
18
C84H145N21O23
1817.20
10.60
+2
-1.58
0.811
Evidence Records 11 records
Evidence 1 Activity

Activity

MIC
Antibacterial
40-50 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Moderately active against E. coli (MIC 40-50 uM) and highly active against S. aureus ATCC 25923 and MRSA (MIC 2.5-5 uM). The 2000 paper re
Evidence 2 Activity

Activity

MIC
Antibacterial
2.5-5 µM

Target

Staphylococcus aureus ATCC 25923 and MRSA

Source & Reference

dbAMP DRAMP

Other

Moderately active against E. coli (MIC 40-50 uM) and highly active against S. aureus ATCC 25923 and MRSA (MIC 2.5-5 uM). The 2000 paper reported an MIC 80 uM against S. aureus for XT-6 isolated from Xenopus tr
Evidence 3 Activity

Activity

MIC
Antifungal
40-50 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Moderately active against E. coli (MIC 40-50 uM) and highly active against S. aureus ATCC 25923 and MRSA (MIC 2.5-5 uM). The 2000 paper re
Evidence 4 Activity

Activity

MIC
Antifungal
2.5-5 µM

Target

Staphylococcus aureus ATCC 25923 and MRSA

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Moderately active against E. coli (MIC 40-50 uM) and highly active against S. aureus ATCC 25923 and MRSA (MIC 2.5-5 uM). The 2000 paper reported an MIC 80 uM against S. aureus for XT-6 isolated from Xenopus tr
Evidence 5 Activity

Activity

MIC
Antiparasitic
40-50 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Moderately active against E. coli (MIC 40-50 uM) and highly active against S. aureus ATCC 25923 and MRSA (MIC 2.5-5 uM). The 2000 paper re
Evidence 6 Activity

Activity

MIC
Antiparasitic
2.5-5 µM

Target

Staphylococcus aureus ATCC 25923 and MRSA

Source & Reference

DRAMP

Other

Moderately active against E. coli (MIC 40-50 uM) and highly active against S. aureus ATCC 25923 and MRSA (MIC 2.5-5 uM). The 2000 paper reported an MIC 80 uM against S. aureus for XT-6 isolated from Xenopus tr
Evidence 7 Activity

Activity

HC50
Hemolysis
70 µM
[Ref.11738090]HC50=70 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Biochim Biophys Acta. 2001 Nov 26 1550(1):81-89.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 8 Activity

Activity

50% Hemolysis
Toxicity
220 µM
Hemolytic Cytotoxic
50% Hemolysis | 220 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Host-defense peptides in skin secretions of the tetraploid frog Silurana epitropicalis with potent activity against methicillin-resistant Staphylococcus aureus (MRSA). | Peptides | 2012
Evidence 9 Activity

Activity

50% Hemolysis
Toxicity
>150 µM
Hemolytic Cytotoxic
50% Hemolysis | >150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae). | Biochim Biophys Acta | 2001
Evidence 10 Activity

Activity

HC50
Toxicity
70 µM
Hemolytic
Hemolytic_activity: [Ref.11738090]HC50=70 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta. 2001 Nov 26 1550(1):81-89.
Evidence 11 Hemolysis

Activity

70 µM
HC50
[Ref.11738090]HC50=70 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
Biochim Biophys Acta. 2001 Nov 26 1550(1):81-89.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.