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Peptide record

TPDB08967

Maculatin 2.1 Antibacterial Anticancer Antifungal Antiparasitic standard

18 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB08967

Peptide_Name

Maculatin 2.1

Activity

Antibacterial Anticancer Antifungal Antiparasitic

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GFVDFLKKVAGTIANVVT

FASTA

>TPDB08967|Antibacterial;Anticancer;Antifungal;Antiparasitic|length=18
GFVDFLKKVAGTIANVVT

Formula C88H143N21O24

Absent Amino Acids RCEQHMPSWY

Common Amino Acids V

Mass 1879.23

PI 9.88

Basic Residues 2

Acidic Residues 1

Hydrophobic Residues 10

Net Charge +1

Boman Index 0.74

Hydrophobicity 0.961

Aliphatic Index 118.89

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

Amino Acid Distribution

A: 2 R: 0 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 1 K: 2 M: 0 F: 2 P: 0 S: 0 T: 2 W: 0 Y: 0 V: 4

Length

Formula

C88H143N21O24

Mass

1879.23

9.88

Net Charge

Boman Index

0.74

Hydrophobicity

0.961

C_terminal_Modification

Free

Chirality

Linear_or_Cyclic

Not Available

N_terminal_Modification

Free

Nature

Antibacterial

Origin

Litoria genimaculate, Litoria eucnemis, Australia

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 100 µg/mL

Target

Target Organism B. cereus

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against B. cereus (MIC 100 ug/ml), E.coli (MIC> 100 ug/ml), L.lactis (MIC>100 ug/ml), L. innocua (MIC 100 ug/ml), M. luteus

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism L.lactis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against B. cereus (MIC 100 ug/ml), E.coli (MIC> 100 ug/ml), L.lactis (MIC>100 ug/ml), L. innocua (MIC 100 ug/ml), M. luteus (MIC 100 ug/ml), P.multocida (MIC>100 ug/ml), S. a

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 100 µg/mL

Target

Target Organism L. innocua

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ive against B. cereus (MIC 100 ug/ml), E.coli (MIC> 100 ug/ml), L.lactis (MIC>100 ug/ml), L. innocua (MIC 100 ug/ml), M. luteus (MIC 100 ug/ml), P.multocida (MIC>100 ug/ml), S. aureus (MIC 100 ug/ml), S. ep

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 100 µg/mL

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

00 ug/ml), E.coli (MIC> 100 ug/ml), L.lactis (MIC>100 ug/ml), L. innocua (MIC 100 ug/ml), M. luteus (MIC 100 ug/ml), P.multocida (MIC>100 ug/ml), S. aureus (MIC 100 ug/ml), S. epidermidis (MIC 50 ug/ml), S

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism P.multocida

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ug/ml), L.lactis (MIC>100 ug/ml), L. innocua (MIC 100 ug/ml), M. luteus (MIC 100 ug/ml), P.multocida (MIC>100 ug/ml), S. aureus (MIC 100 ug/ml), S. epidermidis (MIC 50 ug/ml), S.faecalis (MIC>100 ug/ml), an

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 100 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

/ml), L. innocua (MIC 100 ug/ml), M. luteus (MIC 100 ug/ml), P.multocida (MIC>100 ug/ml), S. aureus (MIC 100 ug/ml), S. epidermidis (MIC 50 ug/ml), S.faecalis (MIC>100 ug/ml), and S. uberis (MIC 25 ug/ml).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µg/mL

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

g/ml), M. luteus (MIC 100 ug/ml), P.multocida (MIC>100 ug/ml), S. aureus (MIC 100 ug/ml), S. epidermidis (MIC 50 ug/ml), S.faecalis (MIC>100 ug/ml), and S. uberis (MIC 25 ug/ml). Updated 12/2010 Jan2023 12/2

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism S.faecalis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

), P.multocida (MIC>100 ug/ml), S. aureus (MIC 100 ug/ml), S. epidermidis (MIC 50 ug/ml), S.faecalis (MIC>100 ug/ml), and S. uberis (MIC 25 ug/ml). Updated 12/2010 Jan2023 12/2024.

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µg/mL

Target

Target Organism S. uberis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

S. aureus (MIC 100 ug/ml), S. epidermidis (MIC 50 ug/ml), S.faecalis (MIC>100 ug/ml), and S. uberis (MIC 25 ug/ml). Updated 12/2010 Jan2023 12/2024.

Evidence 10 Activity

Activity

Activity Raw

Not Available

Detail Source Activity Anticancer

Target

Cancer Type Not Available

Cell Line Not Available

Tissue Affected Not Available

Assay & Model

Assay Not Available

Testing Time Not Available

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1998

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 100 µg/mL

Target

Target Organism B. cereus

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against B. cereus (MIC 100 ug/ml), E.coli (MIC> 100 ug/ml), L.lactis (MIC>100 ug/ml), L. innocua (MIC 100 ug/ml), M. luteus

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism L.lactis

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Active against B. cereus (MIC 100 ug/ml), E.coli (MIC> 100 ug/ml), L.lactis (MIC>100 ug/ml), L. innocua (MIC 100 ug/ml), M. luteus (MIC 100 ug/ml), P.multocida (MIC>100 ug/ml), S. a

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 100 µg/mL

Target

Target Organism L. innocua

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 100 µg/mL

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism P.multocida

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 100 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 50 µg/mL

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism S.faecalis

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

), P.multocida (MIC>100 ug/ml), S. aureus (MIC 100 ug/ml), S. epidermidis (MIC 50 ug/ml), S.faecalis (MIC>100 ug/ml), and S. uberis (MIC 25 ug/ml). Updated 12/2010 Jan2023 12/2024.

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µg/mL

Target

Target Organism S. uberis

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

S. aureus (MIC 100 ug/ml), S. epidermidis (MIC 50 ug/ml), S.faecalis (MIC>100 ug/ml), and S. uberis (MIC 25 ug/ml). Updated 12/2010 Jan2023 12/2024.

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 100 µg/mL

Target

Target Organism B. cereus

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against B. cereus (MIC 100 ug/ml), E.coli (MIC> 100 ug/ml), L.lactis (MIC>100 ug/ml), L. innocua (MIC 100 ug/ml), M. luteus

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism L.lactis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against B. cereus (MIC 100 ug/ml), E.coli (MIC> 100 ug/ml), L.lactis (MIC>100 ug/ml), L. innocua (MIC 100 ug/ml), M. luteus (MIC 100 ug/ml), P.multocida (MIC>100 ug/ml), S. a

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 100 µg/mL

Target

Target Organism L. innocua

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 100 µg/mL

Target

Target Organism M. luteus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism P.multocida

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 100 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 50 µg/mL

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism S.faecalis

Source & Reference

Database Source DRAMP

Other

Evidence Text

), P.multocida (MIC>100 ug/ml), S. aureus (MIC 100 ug/ml), S. epidermidis (MIC 50 ug/ml), S.faecalis (MIC>100 ug/ml), and S. uberis (MIC 25 ug/ml). Updated 12/2010 Jan2023 12/2024.

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 25 µg/mL

Target

Target Organism S. uberis

Source & Reference

Database Source DRAMP

Other

Evidence Text

S. aureus (MIC 100 ug/ml), S. epidermidis (MIC 50 ug/ml), S.faecalis (MIC>100 ug/ml), and S. uberis (MIC 25 ug/ml). Updated 12/2010 Jan2023 12/2024.