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Peptide record

TPDB08966

CPF-ST3 Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08966
CPF-ST3
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab AFP-GFuse Antifungipept CAFPdb i2APP APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLLGPLLKIAAKVGSNLL
Physicochemical Analysis
C83H149N21O21
RDCEQHMFTWY
L
1777.22
10.60
2
0
10
+2
-0.93
1.122
178.89
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
0
E
0
Q
3
G
0
H
1
I
6
L
2
K
0
M
0
F
1
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 6 K: 2 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
18
C83H149N21O21
1777.22
10.60
+2
-0.93
1.122
Free
L
Not Available
Free
Anticancer
Diploid clawed frogXenopus tropicalis, Africa
Evidence Records 29 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5-7 µM

Target

Staphylococcus aureus or MRSA

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Strongly active against S. aureus or MRSA (MIC 5-7 uM), S. epidermidis (MIC 3 uM), S. saprophyticus (MIC 13 uM), Streptococcus group C (MIC 3 uM
Evidence 2 Activity

Activity

MIC
Antibacterial
3 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP

Other

Strongly active against S. aureus or MRSA (MIC 5-7 uM), S. epidermidis (MIC 3 uM), S. saprophyticus (MIC 13 uM), Streptococcus group C (MIC 3 uM), S. sonnei (MIC 35 uM), E
Evidence 3 Activity

Activity

MIC
Antibacterial
13 µM

Target

S. saprophyticus

Source & Reference

dbAMP DRAMP

Other

Strongly active against S. aureus or MRSA (MIC 5-7 uM), S. epidermidis (MIC 3 uM), S. saprophyticus (MIC 13 uM), Streptococcus group C (MIC 3 uM), S. sonnei (MIC 35 uM), E. coli (MIC 6 uM), P. aerugino
Evidence 4 Activity

Activity

MIC
Antibacterial
35 µM

Target

S. sonnei

Source & Reference

dbAMP DRAMP

Other

. epidermidis (MIC 3 uM), S. saprophyticus (MIC 13 uM), Streptococcus group C (MIC 3 uM), S. sonnei (MIC 35 uM), E. coli (MIC 6 uM), P. aeruginosa (MIC 60 uM), E. cloacae (MIC 35 uM), C. albicans (MIC
Evidence 5 Activity

Activity

MIC
Antibacterial
6 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

), S. saprophyticus (MIC 13 uM), Streptococcus group C (MIC 3 uM), S. sonnei (MIC 35 uM), E. coli (MIC 6 uM), P. aeruginosa (MIC 60 uM), E. cloacae (MIC 35 uM), C. albicans (MIC 40-56 uM).
Evidence 6 Activity

Activity

MIC
Antibacterial
60 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

(MIC 13 uM), Streptococcus group C (MIC 3 uM), S. sonnei (MIC 35 uM), E. coli (MIC 6 uM), P. aeruginosa (MIC 60 uM), E. cloacae (MIC 35 uM), C. albicans (MIC 40-56 uM).
Evidence 7 Activity

Activity

MIC
Antibacterial
35 µM

Target

Enterobacter cloacae

Source & Reference

dbAMP DRAMP

Other

group C (MIC 3 uM), S. sonnei (MIC 35 uM), E. coli (MIC 6 uM), P. aeruginosa (MIC 60 uM), E. cloacae (MIC 35 uM), C. albicans (MIC 40-56 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
40-56 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

onnei (MIC 35 uM), E. coli (MIC 6 uM), P. aeruginosa (MIC 60 uM), E. cloacae (MIC 35 uM), C. albicans (MIC 40-56 uM).
Evidence 9 Activity

Activity

Not Available
Anticancer

Target

Skin Cancer
Not Available
Not Available

Assay & Model

Not Available
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2001

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 10 Activity

Activity

MIC
Antifungal
5-7 µM

Target

Staphylococcus aureus or MRSA

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Strongly active against S. aureus or MRSA (MIC 5-7 uM), S. epidermidis (MIC 3 uM), S. saprophyticus (MIC 13 uM), Streptococcus group C (MIC 3 uM
Evidence 11 Activity

Activity

MIC
Antifungal
3 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Strongly active against S. aureus or MRSA (MIC 5-7 uM), S. epidermidis (MIC 3 uM), S. saprophyticus (MIC 13 uM), Streptococcus group C (MIC 3 uM), S. sonnei (MIC 35 uM), E
Evidence 12 Activity

Activity

MIC
Antifungal
13 µM

Target

S. saprophyticus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Strongly active against S. aureus or MRSA (MIC 5-7 uM), S. epidermidis (MIC 3 uM), S. saprophyticus (MIC 13 uM), Streptococcus group C (MIC 3 uM), S. sonnei (MIC 35 uM), E. coli (MIC 6 uM), P. aerugino
Evidence 13 Activity

Activity

MIC
Antifungal
35 µM

Target

S. sonnei

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

. epidermidis (MIC 3 uM), S. saprophyticus (MIC 13 uM), Streptococcus group C (MIC 3 uM), S. sonnei (MIC 35 uM), E. coli (MIC 6 uM), P. aeruginosa (MIC 60 uM), E. cloacae (MIC 35 uM), C. albicans (MIC
Evidence 14 Activity

Activity

MIC
Antifungal
6 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

), S. saprophyticus (MIC 13 uM), Streptococcus group C (MIC 3 uM), S. sonnei (MIC 35 uM), E. coli (MIC 6 uM), P. aeruginosa (MIC 60 uM), E. cloacae (MIC 35 uM), C. albicans (MIC 40-56 uM).
Evidence 15 Activity

Activity

MIC
Antifungal
60 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC 13 uM), Streptococcus group C (MIC 3 uM), S. sonnei (MIC 35 uM), E. coli (MIC 6 uM), P. aeruginosa (MIC 60 uM), E. cloacae (MIC 35 uM), C. albicans (MIC 40-56 uM).
Evidence 16 Activity

Activity

MIC
Antifungal
35 µM

Target

Enterobacter cloacae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

group C (MIC 3 uM), S. sonnei (MIC 35 uM), E. coli (MIC 6 uM), P. aeruginosa (MIC 60 uM), E. cloacae (MIC 35 uM), C. albicans (MIC 40-56 uM).
Evidence 17 Activity

Activity

MIC
Antifungal
40-56 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

onnei (MIC 35 uM), E. coli (MIC 6 uM), P. aeruginosa (MIC 60 uM), E. cloacae (MIC 35 uM), C. albicans (MIC 40-56 uM).
Evidence 18 Activity

Activity

MIC
Antiparasitic
5-7 µM

Target

Staphylococcus aureus or MRSA

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Strongly active against S. aureus or MRSA (MIC 5-7 uM), S. epidermidis (MIC 3 uM), S. saprophyticus (MIC 13 uM), Streptococcus group C (MIC 3 uM
Evidence 19 Activity

Activity

MIC
Antiparasitic
3 µM

Target

Staphylococcus epidermidis

Source & Reference

DRAMP

Other

Strongly active against S. aureus or MRSA (MIC 5-7 uM), S. epidermidis (MIC 3 uM), S. saprophyticus (MIC 13 uM), Streptococcus group C (MIC 3 uM), S. sonnei (MIC 35 uM), E
Evidence 20 Activity

Activity

MIC
Antiparasitic
13 µM

Target

S. saprophyticus

Source & Reference

DRAMP

Other

Strongly active against S. aureus or MRSA (MIC 5-7 uM), S. epidermidis (MIC 3 uM), S. saprophyticus (MIC 13 uM), Streptococcus group C (MIC 3 uM), S. sonnei (MIC 35 uM), E. coli (MIC 6 uM), P. aerugino
Evidence 21 Activity

Activity

MIC
Antiparasitic
35 µM

Target

S. sonnei

Source & Reference

DRAMP

Other

. epidermidis (MIC 3 uM), S. saprophyticus (MIC 13 uM), Streptococcus group C (MIC 3 uM), S. sonnei (MIC 35 uM), E. coli (MIC 6 uM), P. aeruginosa (MIC 60 uM), E. cloacae (MIC 35 uM), C. albicans (MIC
Evidence 22 Activity

Activity

MIC
Antiparasitic
6 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

), S. saprophyticus (MIC 13 uM), Streptococcus group C (MIC 3 uM), S. sonnei (MIC 35 uM), E. coli (MIC 6 uM), P. aeruginosa (MIC 60 uM), E. cloacae (MIC 35 uM), C. albicans (MIC 40-56 uM).
Evidence 23 Activity

Activity

MIC
Antiparasitic
60 µM

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

(MIC 13 uM), Streptococcus group C (MIC 3 uM), S. sonnei (MIC 35 uM), E. coli (MIC 6 uM), P. aeruginosa (MIC 60 uM), E. cloacae (MIC 35 uM), C. albicans (MIC 40-56 uM).
Evidence 24 Activity

Activity

MIC
Antiparasitic
35 µM

Target

Enterobacter cloacae

Source & Reference

DRAMP

Other

group C (MIC 3 uM), S. sonnei (MIC 35 uM), E. coli (MIC 6 uM), P. aeruginosa (MIC 60 uM), E. cloacae (MIC 35 uM), C. albicans (MIC 40-56 uM).
Evidence 25 Activity

Activity

MIC
Antiparasitic
40-56 µM

Target

Candida albicans

Source & Reference

DRAMP

Other

onnei (MIC 35 uM), E. coli (MIC 6 uM), P. aeruginosa (MIC 60 uM), E. cloacae (MIC 35 uM), C. albicans (MIC 40-56 uM).
Evidence 26 Activity

Activity

50% Hemolysis
Toxicity
140 µM
Hemolytic Cytotoxic
50% Hemolysis | 140 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of potent, non-toxic antimicrobial agents based upon the naturally occurring frog skin peptides, ascaphin-8 and peptide XT-7. | Chem Biol Drug Des | 2008
Evidence 27 Activity

Activity

50% Hemolysis
Toxicity
110 µM
Hemolytic Cytotoxic
50% Hemolysis | 110 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Improving the selectivity of antimicrobial peptides from anuran skin. | J Chem Inf Model | 2012
Evidence 28 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae). | Biochim Biophys Acta | 2001
Evidence 29 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.