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Peptide record

TPDB08962

Antibacterial Antifungal Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08962
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLAANFLPKIFCKITRKC
Physicochemical Analysis
C93H155N25O21S2
DEQHMSWYV
K
2023.53
10.32
4
0
8
+4
-0.02
0.467
97.78
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
6.18
4
Residue Composition
number
2
A
1
R
1
N
0
D
2
C
0
E
0
Q
1
G
0
H
2
I
2
L
3
K
0
M
2
F
1
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 2 K: 3 M: 0 F: 2 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C93H155N25O21S2
2023.53
10.32
+4
-0.02
0.467
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
146 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 146 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Structure-activity analysis of brevinin 1E amide, an antimicrobial peptide from Rana esculenta. | Biochim Biophys Acta | 1998
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
230 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 230 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Structure-activity analysis of brevinin 1E amide, an antimicrobial peptide from Rana esculenta. | Biochim Biophys Acta | 1998
Evidence 3 Activity

Activity

HD50
Toxicity
146 µg/mL
Hemolytic
Hemolytic_activity: [Ref.9748603]HD50=146 µg/ml(oxidized) HD50=230 µg/ml(reduced) against mouse red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta. 1998 Sep 8 1387(1-2):239-48.