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Peptide record

TPDB08961

Antibacterial Anticancer Antiparasitic Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08961
Antibacterial Anticancer Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF dbAMP 3.0 HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, Peptipedia, ACP740 _ACP240, and other sources, with an available 3D structural model.
Sequence
GIIKKIIKKIIKKIIKKI
Physicochemical Analysis
C104H200N26O19
ARNDCEQHLMFPSTWYV
I
2118.89
11.36
8
0
9
+8
5.14
0.494
195.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
9
I
0
L
8
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 9 L: 0 K: 8 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C104H200N26O19
2118.89
11.36
+8
5.14
0.494
Evidence Records 17 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

NA

Other

active against S. aureus ATCC 25923 (MIC 4 uM), B. subtilis ATCC 23857 (MIC 0.5-2 uM), K. pneumoniae ATCC 700603 (MIC 8 uM), E. coli ATC
Evidence 2 Activity

Activity

MIC
Antibacterial
0.5-2 µM

Target

B. subtilis ATCC 23857

Source & Reference

NA

Other

active against S. aureus ATCC 25923 (MIC 4 uM), B. subtilis ATCC 23857 (MIC 0.5-2 uM), K. pneumoniae ATCC 700603 (MIC 8 uM), E. coli ATCC 25922 (MIC 2-8 uM), P. aeruginosa ATC
Evidence 3 Activity

Activity

MIC
Antibacterial
8 µM

Target

Klebsiella pneumoniae ATCC 700603

Source & Reference

NA

Other

active against S. aureus ATCC 25923 (MIC 4 uM), B. subtilis ATCC 23857 (MIC 0.5-2 uM), K. pneumoniae ATCC 700603 (MIC 8 uM), E. coli ATCC 25922 (MIC 2-8 uM), P. aeruginosa ATCC 27853 (MIC 4 uM), A. baumannii ATCC
Evidence 4 Activity

Activity

MIC
Antibacterial
2-8 µM

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

(MIC 4 uM), B. subtilis ATCC 23857 (MIC 0.5-2 uM), K. pneumoniae ATCC 700603 (MIC 8 uM), E. coli ATCC 25922 (MIC 2-8 uM), P. aeruginosa ATCC 27853 (MIC 4 uM), A. baumannii ATCC 19606 (MIC 4 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
4 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

NA

Other

57 (MIC 0.5-2 uM), K. pneumoniae ATCC 700603 (MIC 8 uM), E. coli ATCC 25922 (MIC 2-8 uM), P. aeruginosa ATCC 27853 (MIC 4 uM), A. baumannii ATCC 19606 (MIC 4 uM).
Evidence 6 Activity

Activity

MIC
Antibacterial
4 µM

Target

A. baumannii ATCC 19606

Source & Reference

NA

Other

700603 (MIC 8 uM), E. coli ATCC 25922 (MIC 2-8 uM), P. aeruginosa ATCC 27853 (MIC 4 uM), A. baumannii ATCC 19606 (MIC 4 uM).
Evidence 7 Activity

Activity

MIC
Antiparasitic
4 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
active against S. aureus ATCC 25923 (MIC 4 uM), B. subtilis ATCC 23857 (MIC 0.5-2 uM), K. pneumoniae ATCC 700603 (MIC 8 uM), E. coli ATC
Evidence 8 Activity

Activity

MIC
Antiparasitic
0.5-2 µM

Target

B. subtilis ATCC 23857

Source & Reference

dbAMP 3.0

Other

active against S. aureus ATCC 25923 (MIC 4 uM), B. subtilis ATCC 23857 (MIC 0.5-2 uM), K. pneumoniae ATCC 700603 (MIC 8 uM), E. coli ATCC 25922 (MIC 2-8 uM), P. aeruginosa ATC
Evidence 9 Activity

Activity

MIC
Antiparasitic
8 µM

Target

Klebsiella pneumoniae ATCC 700603

Source & Reference

dbAMP 3.0

Other

active against S. aureus ATCC 25923 (MIC 4 uM), B. subtilis ATCC 23857 (MIC 0.5-2 uM), K. pneumoniae ATCC 700603 (MIC 8 uM), E. coli ATCC 25922 (MIC 2-8 uM), P. aeruginosa ATCC 27853 (MIC 4 uM), A. baumannii ATCC
Evidence 10 Activity

Activity

MIC
Antiparasitic
2-8 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP 3.0

Other

(MIC 4 uM), B. subtilis ATCC 23857 (MIC 0.5-2 uM), K. pneumoniae ATCC 700603 (MIC 8 uM), E. coli ATCC 25922 (MIC 2-8 uM), P. aeruginosa ATCC 27853 (MIC 4 uM), A. baumannii ATCC 19606 (MIC 4 uM).
Evidence 11 Activity

Activity

MIC
Antiparasitic
4 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP 3.0

Other

57 (MIC 0.5-2 uM), K. pneumoniae ATCC 700603 (MIC 8 uM), E. coli ATCC 25922 (MIC 2-8 uM), P. aeruginosa ATCC 27853 (MIC 4 uM), A. baumannii ATCC 19606 (MIC 4 uM).
Evidence 12 Activity

Activity

MIC
Antiparasitic
4 µM

Target

A. baumannii ATCC 19606

Source & Reference

dbAMP 3.0

Other

700603 (MIC 8 uM), E. coli ATCC 25922 (MIC 2-8 uM), P. aeruginosa ATCC 27853 (MIC 4 uM), A. baumannii ATCC 19606 (MIC 4 uM).
Evidence 13 Activity

Activity

50% Hemolysis
Toxicity
41±2 µM
Hemolytic Cytotoxic
50% Hemolysis | 41±2 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Designed antimicrobial and antitumor peptides with high selectivity. | Biomacromolecules | 2011
Evidence 14 Activity

Activity

10% Hemolysis
Toxicity
6.887 µM
Hemolytic Cytotoxic
10% Hemolysis | 6.887 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
High Therapeutic Index α-Helical AMPs and Their Therapeutic Potential on Bacterial Lung and Skin Wound Infections. | ACS Infect Dis | 2024
Evidence 15 Activity

Activity

IC50
Toxicity
6.92 µM
Cytotoxic
IC50 | 6.92 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
High Therapeutic Index α-Helical AMPs and Their Therapeutic Potential on Bacterial Lung and Skin Wound Infections. | ACS Infect Dis | 2024
Evidence 16 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Biomaterials. 2014 Feb 35(5):1552-61.
Evidence 17 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis