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Peptide record

TPDB08958

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08958
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifp Antifungipept CAFPdb dbAMP
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
RGLRRLGRKIAHGVKKYG
Physicochemical Analysis
C91H161N35O20
NDCEQMFPSTW
RG
2065.50
12.42
8
0
6
+7
4.74
-0.983
86.67
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
72.14
1
Residue Composition
number
1
A
4
R
0
N
0
D
0
C
0
E
0
Q
4
G
1
H
1
I
2
L
3
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 1 I: 1 L: 2 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
18
C91H161N35O20
2065.50
12.42
+7
4.74
-0.983
Evidence Records 23 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8 µM

Target

B. subtilis

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram+ B. subtilis (MIC 8 uM), S. epidermidis (MIC 4 uM), S. aureus (MIC 8 uM), Gram- E. coli (MIC 4 uM), S. typhimuriu
Evidence 2 Activity

Activity

MIC
Antibacterial
4 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP

Other

Active against Gram+ B. subtilis (MIC 8 uM), S. epidermidis (MIC 4 uM), S. aureus (MIC 8 uM), Gram- E. coli (MIC 4 uM), S. typhimurium (MIC 8 uM), and P. aerugi
Evidence 3 Activity

Activity

MIC
Antibacterial
8 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP

Other

Active against Gram+ B. subtilis (MIC 8 uM), S. epidermidis (MIC 4 uM), S. aureus (MIC 8 uM), Gram- E. coli (MIC 4 uM), S. typhimurium (MIC 8 uM), and P. aeruginosa (MIC 8 uM) ( June
Evidence 4 Activity

Activity

MIC
Antibacterial
4 µM

Target

Escherichia coli

Source & Reference

dbAMP

Other

inst Gram+ B. subtilis (MIC 8 uM), S. epidermidis (MIC 4 uM), S. aureus (MIC 8 uM), Gram- E. coli (MIC 4 uM), S. typhimurium (MIC 8 uM), and P. aeruginosa (MIC 8 uM) ( June et al., 2023 ).
Evidence 5 Activity

Activity

MIC
Antibacterial
8 µM

Target

S. typhimurium

Source & Reference

dbAMP

Other

is (MIC 8 uM), S. epidermidis (MIC 4 uM), S. aureus (MIC 8 uM), Gram- E. coli (MIC 4 uM), S. typhimurium (MIC 8 uM), and P. aeruginosa (MIC 8 uM) ( June et al., 2023 ).
Evidence 6 Activity

Activity

MIC
Antibacterial
8 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP

Other

MIC 4 uM), S. aureus (MIC 8 uM), Gram- E. coli (MIC 4 uM), S. typhimurium (MIC 8 uM), and P. aeruginosa (MIC 8 uM) ( June et al., 2023 ).
Evidence 7 Activity

Activity

MIC
Antifungal
8 µM

Target

B. subtilis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram+ B. subtilis (MIC 8 uM), S. epidermidis (MIC 4 uM), S. aureus (MIC 8 uM), Gram- E. coli (MIC 4 uM), S. typhimuriu
Evidence 8 Activity

Activity

MIC
Antifungal
4 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram+ B. subtilis (MIC 8 uM), S. epidermidis (MIC 4 uM), S. aureus (MIC 8 uM), Gram- E. coli (MIC 4 uM), S. typhimurium (MIC 8 uM), and P. aerugi
Evidence 9 Activity

Activity

MIC
Antifungal
8 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram+ B. subtilis (MIC 8 uM), S. epidermidis (MIC 4 uM), S. aureus (MIC 8 uM), Gram- E. coli (MIC 4 uM), S. typhimurium (MIC 8 uM), and P. aeruginosa (MIC 8 uM) ( June
Evidence 10 Activity

Activity

MIC
Antifungal
4 µM

Target

Escherichia coli

Source & Reference

dbAMP CAFPdb Antifungipept

Other

inst Gram+ B. subtilis (MIC 8 uM), S. epidermidis (MIC 4 uM), S. aureus (MIC 8 uM), Gram- E. coli (MIC 4 uM), S. typhimurium (MIC 8 uM), and P. aeruginosa (MIC 8 uM) ( June et al., 2023 ).
Evidence 11 Activity

Activity

MIC
Antifungal
8 µM

Target

S. typhimurium

Source & Reference

dbAMP CAFPdb Antifungipept

Other

is (MIC 8 uM), S. epidermidis (MIC 4 uM), S. aureus (MIC 8 uM), Gram- E. coli (MIC 4 uM), S. typhimurium (MIC 8 uM), and P. aeruginosa (MIC 8 uM) ( June et al., 2023 ).
Evidence 12 Activity

Activity

MIC
Antifungal
8 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP CAFPdb Antifungipept

Other

MIC 4 uM), S. aureus (MIC 8 uM), Gram- E. coli (MIC 4 uM), S. typhimurium (MIC 8 uM), and P. aeruginosa (MIC 8 uM) ( June et al., 2023 ).
Evidence 13 Activity

Activity

MIC
Antiparasitic
8 µM

Target

B. subtilis

Source & Reference

NA

Other

Active against Gram+ B. subtilis (MIC 8 uM), S. epidermidis (MIC 4 uM), S. aureus (MIC 8 uM), Gram- E. coli (MIC 4 uM), S. typhimuriu
Evidence 14 Activity

Activity

MIC
Antiparasitic
4 µM

Target

Staphylococcus epidermidis

Source & Reference

NA

Other

Active against Gram+ B. subtilis (MIC 8 uM), S. epidermidis (MIC 4 uM), S. aureus (MIC 8 uM), Gram- E. coli (MIC 4 uM), S. typhimurium (MIC 8 uM), and P. aerugi
Evidence 15 Activity

Activity

MIC
Antiparasitic
8 µM

Target

Staphylococcus aureus

Source & Reference

NA

Other

Active against Gram+ B. subtilis (MIC 8 uM), S. epidermidis (MIC 4 uM), S. aureus (MIC 8 uM), Gram- E. coli (MIC 4 uM), S. typhimurium (MIC 8 uM), and P. aeruginosa (MIC 8 uM) ( June
Evidence 16 Activity

Activity

MIC
Antiparasitic
4 µM

Target

Escherichia coli

Source & Reference

NA

Other

inst Gram+ B. subtilis (MIC 8 uM), S. epidermidis (MIC 4 uM), S. aureus (MIC 8 uM), Gram- E. coli (MIC 4 uM), S. typhimurium (MIC 8 uM), and P. aeruginosa (MIC 8 uM) ( June et al., 2023 ).
Evidence 17 Activity

Activity

MIC
Antiparasitic
8 µM

Target

S. typhimurium

Source & Reference

NA

Other

is (MIC 8 uM), S. epidermidis (MIC 4 uM), S. aureus (MIC 8 uM), Gram- E. coli (MIC 4 uM), S. typhimurium (MIC 8 uM), and P. aeruginosa (MIC 8 uM) ( June et al., 2023 ).
Evidence 18 Activity

Activity

MIC
Antiparasitic
8 µM

Target

Pseudomonas aeruginosa

Source & Reference

NA

Other

MIC 4 uM), S. aureus (MIC 8 uM), Gram- E. coli (MIC 4 uM), S. typhimurium (MIC 8 uM), and P. aeruginosa (MIC 8 uM) ( June et al., 2023 ).
Evidence 19 Activity

Activity

50% Hemolysis
Toxicity
>400 µM
Hemolytic Cytotoxic
50% Hemolysis | >400 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Bacterial killing mechanism of sheep myeloid antimicrobial peptide-18 (SMAP-18) and its Trp-substituted analog with improved cell selectivity and reduced mammalian cell toxicity. | Amino Acids | 2014
Evidence 20 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Bacterial killing mechanism of sheep myeloid antimicrobial peptide-18 (SMAP-18) and its Trp-substituted analog with improved cell selectivity and reduced mammalian cell toxicity. | Amino Acids | 2014
Evidence 21 Activity

Activity

10% Hemolysis
Toxicity
512 µM
Hemolytic Cytotoxic
10% Hemolysis | 512 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The Stereochemical Effect of SMAP-29 and SMAP-18 on Bacterial Selectivity, Membrane Interaction and Anti-Inflammatory Activity | Amino Acids | 2016
Evidence 22 Activity

Activity

12% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
12% Hemolysis | 100 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Discovery of structural and functional transition sites for membrane-penetrating activity of sheep myeloid antimicrobial peptide-18. | Sci Rep | 2023
Evidence 23 Activity

Activity

50% Hemolysis
Toxicity
>>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >>100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Analogues of peptide SMAP-29 with comparable antimicrobial potency and reduced cytotoxicity. | Int J Antimicrob Agents | 2011