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Peptide record

TPDB08955

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard

18 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB08955

Activity

Antibacterial Anticancer Antifungal Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP dbAMP 3.0 iACP-DRLF pep-lab Antifungipept CAFPdb HemoPI Hemolytic2 PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

KWKLFKKILKFLHLAKKF

FASTA

>TPDB08955|Antibacterial;Anticancer;Antifungal;Hemolysis;Toxicity|length=18
KWKLFKKILKFLHLAKKF

Formula C119H190N28O19

Absent Amino Acids RNDCEQGMPSTYV

Common Amino Acids K

Mass 2316.99

PI 11.29

Basic Residues 8

Acidic Residues 0

Hydrophobic Residues 10

Net Charge +7

Boman Index -0.07

Hydrophobicity -0.083

Aliphatic Index 113.89

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 237.38

Polar Residues 0

number

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 4 K: 7 M: 0 F: 3 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0

Length

Formula

C119H190N28O19

Mass

2316.99

11.29

Net Charge

Boman Index

-0.07

Hydrophobicity

-0.083

Evidence 1 Activity

Activity

Activity Endpoint 1% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 0.78 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

1% Hemolysis | 0.78 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs. | J Pept Res | 2001

Evidence 2 Activity

Activity

Activity Endpoint 5% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 1.56 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

5% Hemolysis | 1.56 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs. | J Pept Res | 2001

Evidence 3 Activity

Activity

Activity Endpoint 27% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 3.125 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

27% Hemolysis | 3.125 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs. | J Pept Res | 2001

Evidence 4 Activity

Activity

Activity Endpoint 32% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 6.25 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

32% Hemolysis | 6.25 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs. | J Pept Res | 2001

Evidence 5 Activity

Activity

Activity Endpoint 41% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 12.5 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

41% Hemolysis | 12.5 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs. | J Pept Res | 2001

Evidence 6 Activity

Activity

Activity Endpoint 66% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 25 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

66% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs. | J Pept Res | 2001

Evidence 7 Activity

Activity

Activity Endpoint 78% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

78% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs. | J Pept Res | 2001

Evidence 8 Activity

Activity

Activity Endpoint 89% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

89% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs. | J Pept Res | 2001

Evidence 9 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 70.0 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 70.0 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Target Cell Mouse fibroblasts NIH 3T3

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs. | J Pept Res | 2001

Evidence 10 Hemolysis

Source & Reference

source HemoPI PD_Hemolysis

Database Source PD_Hemolysis