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Peptide record

TPDB08949

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08949
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb PD_Hemolysis ToxinPred 3.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FPFSLIPHAIGGLISAIK
Physicochemical Analysis
C92H145N21O21
RNDCEQMTWYV
I
1881.29
10.10
2
0
10
+1
-1.83
1.228
141.11
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
1
H
4
I
2
L
1
K
0
M
2
F
2
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 1 I: 4 L: 2 K: 1 M: 0 F: 2 P: 2 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C92H145N21O21
1881.29
10.10
+1
-1.83
1.228
Evidence Records 8 records
Evidence 1 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog. | Peptides | 2012
Evidence 2 Activity

Activity

75% Hemolysis
Toxicity
120 µM
Hemolytic Cytotoxic
75% Hemolysis | 120 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog. | Peptides | 2012
Evidence 3 Activity

Activity

46% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
46% Hemolysis | 100 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog. | Peptides | 2012
Evidence 4 Activity

Activity

37% Hemolysis
Toxicity
80 µM
Hemolytic Cytotoxic
37% Hemolysis | 80 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog. | Peptides | 2012
Evidence 5 Activity

Activity

36% Hemolysis
Toxicity
60 µM
Hemolytic Cytotoxic
36% Hemolysis | 60 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog. | Peptides | 2012
Evidence 6 Activity

Activity

25% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
25% Hemolysis | 40 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog. | Peptides | 2012
Evidence 7 Activity

Activity

19% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
19% Hemolysis | 10 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog. | Peptides | 2012
Evidence 8 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis