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Peptide record

TPDB08948

Antibacterial Antifungal Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08948
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FPFLLSLIPSAISAIKRL
Physicochemical Analysis
C97H160N22O22
NDCEQGHMTWYV
L
1986.47
11.49
2
0
11
+2
-2.68
1.328
162.78
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
2
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
3
I
4
L
1
K
0
M
2
F
2
P
3
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 3 L: 4 K: 1 M: 0 F: 2 P: 2 S: 3 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C97H160N22O22
1986.47
11.49
+2
-2.68
1.328
Evidence Records 5 records
Evidence 1 Activity

Activity

EC50
Toxicity
6.29 µM
Cytotoxic
EC50 | 6.29 | µM | target cell: Baby Hamster Kidney cells BHK-21

Target

Baby Hamster Kidney cells BHK-21

Source & Reference

NA
DBAASP
Bioactivity of Natural and Engineered Antimicrobial Peptides from Venom of the Scorpions Urodacus yaschenkoi and U. manicatus. | Toxins (Basel) | 2017
Evidence 2 Activity

Activity

10% Hemolysis
Toxicity
55.14 µM
Hemolytic Cytotoxic
10% Hemolysis | 55.14 | µM | target cell: Pig erythrocytes

Target

Pig erythrocytes

Source & Reference

NA
DBAASP
Bioactivity of Natural and Engineered Antimicrobial Peptides from Venom of the Scorpions Urodacus yaschenkoi and U. manicatus. | Toxins (Basel) | 2017
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
104.50 µM
Hemolytic Cytotoxic
50% Hemolysis | 104.50 | µM | target cell: Pig erythrocytes

Target

Pig erythrocytes

Source & Reference

NA
DBAASP
Bioactivity of Natural and Engineered Antimicrobial Peptides from Venom of the Scorpions Urodacus yaschenkoi and U. manicatus. | Toxins (Basel) | 2017
Evidence 4 Activity

Activity

90% Hemolysis
Toxicity
198.04 µM
Hemolytic Cytotoxic
90% Hemolysis | 198.04 | µM | target cell: Pig erythrocytes

Target

Pig erythrocytes

Source & Reference

NA
DBAASP
Bioactivity of Natural and Engineered Antimicrobial Peptides from Venom of the Scorpions Urodacus yaschenkoi and U. manicatus. | Toxins (Basel) | 2017
Evidence 5 Activity

Activity

25% Hemolysis
Toxicity
370 µM
Hemolytic Cytotoxic
25% Hemolysis | 370 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural Characterization of Scorpion Peptides and Their Bactericidal Activity Against Clinical Isolates of Multidrug-Resistant Bacteria. | PLoS One | 2019