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Peptide record

TPDB08945

mVE-cadherin-anti-gyrA PNA/scPNA PTD7 (pVEC) pVEC VEC Antibacterial Antifungal Antiparasitic Blood-Brain Barrier Cell-penetrating Peptides Toxicity Tumor-homing Peptides standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08945
mVE-cadherin-anti-gyrA PNA/scPNA PTD7 (pVEC) pVEC VEC
Antibacterial Antifungal Antiparasitic Blood-Brain Barrier Cell-penetrating Peptides Toxicity Tumor-homing Peptides
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP i2APP B3Pred BBPpredict CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP TumorHoPe2.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
LLIILRRRIRKQAHAHSK
Physicochemical Analysis
C98H177N37O21
NDCEGMFPTWYV
R
2209.72
12.88
8
0
8
+6
4.90
-0.444
141.11
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
2
A
4
R
0
N
0
D
0
C
0
E
1
Q
0
G
2
H
3
I
3
L
2
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 2 I: 3 L: 3 K: 2 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C98H177N37O21
2209.72
12.88
+6
4.90
-0.444
Free
L
Amphipathic
Linear
Free
N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)O NCC(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)O N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)O N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H](Cc1ccccc1)C(=O)/N=C/C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 13 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO-K1 and WM266-1 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Protein derived
Nucleic acid (Plasmid DNA)
Cytoplasm
High
Direct cellular penetration
In vitro
CCSSCGGGHHHHSCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Vero Cells And Hk-2 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Copper/zinc superoxide dismutase (SOD1)
In vitro
CCSSCGGGHHHHSCCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

S. Aureus Infected Mac-T Or Hbmec Cell Lines , Ex Vivo Calvaria (Skull Cap)

Assay & Model

Femur injury model (Wistar rats (5 to 6 wks of age))
Femur injury model (Wistar rats (5 to 6 wks of age))

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Protein derived
Lysostaphin and LysK
In vitro and in vivo
CCCCCHHHHHCC
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Target

Dc2.4 Dcs , Splenocytes From C57Bl/6 Mice

Assay & Model

C57BL/6 mice
C57BL/6 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
FITC-dye and gp100 peptide to the N terminus
Cytosol
Endocytosis
In vitro and in vivo
CCCCSSSSSCCSSCCCCC
Evidence 5 Activity

Activity

Cell-penetrating Peptides

Target

S. Pyogenes Strains

Assay & Model

G. mellonella Larvae
G. mellonella Larvae

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
anti-gyrA antisense PNAs and scrambled PNAs [scPNAs]
No reduction of CFU per millilitre was observed in S. pyogenes strains. Also did not affect the survival of infected larvae.
In vitro and in vivo
CCTTTCTHHHHHHHTTCC
Evidence 6 Activity

Activity

Cell-penetrating Peptides

Target

E. Coli , C. Crescentus Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
SpyCatcher003 at C-terminus of CPP via GGGS spacer
Cytoplasm
In vitro
CCCTHHHHHHHHTTTSSCSSSHHHHHGGGSCCCC
Evidence 7 Activity

Activity

Cell-penetrating Peptides

Target

Skov-3 And HeLa Cells

Assay & Model

7 week-old female BALB/c mice
7 week-old female BALB/c mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
FITC-labeled Mn:ZnS Nanoparticels loaded with Paclitaxel (PTX)
Intracellular fluorescence was improved with R9-modified NPs compared to the PEN and pVEC which was confirmed by flow cytometry
In vitro and in vivo
CCCSSSTTCCCTTTTC
Evidence 8 Activity

Activity

Cell-penetrating Peptides

Target

HeLa-654 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Linear L Amphipathic
Protein derived
SulfoCy5-labelled PMOs and Rab5a−RFP fusion protein
Nucleus
1.5 times greater than the individual sum of the parts
Endocytosis
In vitro
Evidence 9 Activity

Activity

Cell-penetrating Peptides

Target

Caco-2 Cells Bacteroidetes (Bacteroides Vulgatus And Bacteroides Thetaiotaomicron), Firmicutes (Lactobacillus Gasseri, Latilactobacillus Sakei, And Clostridium Bolteae), Actinomicetya (Bifidobacterium Longum, And Bifidobacterium Adolescentis) , Proteobacteria (Escherichia Coli Nissle 1917 And Escherichia Coli K12) And Saccharomyces Boulardii

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
FITC-dextran
In vitro
CCTTSSCCCCC
Evidence 10 Activity

Activity

50% Hemolysis
Toxicity
>200 µM
Hemolytic Cytotoxic
50% Hemolysis | >200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity, bactericidal mechanism and LPS-neutralizing activity of the cell-penetrating peptide pVEC and its analogs. | J Pept Sci | 2011
Evidence 11 Activity

Activity

0% Hemolysis
Toxicity
2 µM
Hemolytic Cytotoxic
0% Hemolysis | 2 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Cell entry and antimicrobial properties of eukaryotic cell-penetrating peptides. | FASEB J | 2004
Evidence 12 Activity

Activity

1% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
1% Hemolysis | 100 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Cell entry and antimicrobial properties of eukaryotic cell-penetrating peptides. | FASEB J | 2004
Evidence 13 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Breast cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Tumor-Homing Cell-Penetrating Peptide Linked to Colloidal Mesoporous Silica Encapsulated (-)-Epigallocatechin-3-gallate as Drug Delivery System for Breast Cancer Therapy in Vivo
2015
Jie Ding et al. ACS Appl Mater Interfaces. 2015 Aug 19 7(32):18145-55.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Epigallocatechin-3-gallate (EGCG),
Cell penetrating peptide
Additional Detail Fields 2 fields
Epigallocatechin-3-gallate (EGCG),
CCSSCGGGHHHHSCCC CCCCCHHHHHCC CCCCSSSSSCCSSCCCCC CCTTTCTHHHHHHHTTCC CCCTHHHHHHHHTTTSSCSSSHHHHHGGGSCCCC CCCSSSTTCCCTTTTC CCTTSSCCCCC