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Peptide record

TPDB08944

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08944
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb PD_Hemolysis
standard
No
A 18-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLFSLIPKAIGGLISAFK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C96H152N20O21
RNDCEQHMTWYV
ILF
1922.38
10.60
2
0
11
+2
-1.45
1.394
141.11
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
3
I
3
L
2
K
0
M
3
F
1
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 3 K: 2 M: 0 F: 3 P: 1 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18 reviewed residue count
C96H152N20O21 sequence-only estimate (linear, free termini)
1922.38 sequence-only estimate (linear, free termini)
10.60 sequence-only estimate (linear, free termini)
+2 sequence-only estimate (linear, free termini)
-1.45 sequence-only estimate (linear, free termini)
1.394 sequence-only estimate (linear, free termini)
Evidence Records 16 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
195 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 195 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024
Evidence 3 Activity

Activity

85±17.9% Cell death
Toxicity
256 µg/mL
Cytotoxic
85±17.9% Cell death | 256 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024
Evidence 4 Activity

Activity

50% Cell death
Toxicity
121 µg/mL
Cytotoxic
50% Cell death | 121 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024
Evidence 5 Activity

Activity

IC50
Toxicity
40.35 µM
Cytotoxic
IC50 | 40.35 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog. | Peptides | 2012
Evidence 6 Activity

Activity

53% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
53% Hemolysis | 100 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog. | Peptides | 2012
Evidence 7 Activity

Activity

52% Hemolysis
Toxicity
80 µM
Hemolytic Cytotoxic
52% Hemolysis | 80 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog. | Peptides | 2012
Evidence 8 Activity

Activity

51% Hemolysis
Toxicity
60 µM
Hemolytic Cytotoxic
51% Hemolysis | 60 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog. | Peptides | 2012
Evidence 9 Activity

Activity

45% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
45% Hemolysis | 40 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog. | Peptides | 2012
Evidence 10 Activity

Activity

27% Hemolysis
Toxicity
20 µM
Hemolytic Cytotoxic
27% Hemolysis | 20 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog. | Peptides | 2012
Evidence 11 Activity

Activity

18% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
18% Hemolysis | 10 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog. | Peptides | 2012
Evidence 12 Activity

Activity

10% Hemolysis
Toxicity
45 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 45 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024
Evidence 13 Activity

Activity

50% Hemolysis
Toxicity
112 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 112 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024
Evidence 14 Activity

Activity

97.6±12.6% Cell death
Toxicity
256 µg/mL
Cytotoxic
97.6±12.6% Cell death | 256 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024
Evidence 15 Activity

Activity

50% Cell death
Toxicity
59.3 µg/mL
Cytotoxic
50% Cell death | 59.3 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024
Evidence 16 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis