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Peptide record

TPDB08944

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08944
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb PD_Hemolysis
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLFSLIPKAIGGLISAFK
Physicochemical Analysis
C96H152N20O21
RNDCEQHMTWYV
ILF
1922.38
10.60
2
0
11
+2
-3.63
1.394
141.11
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
3
I
3
L
2
K
0
M
3
F
1
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 3 K: 2 M: 0 F: 3 P: 1 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C96H152N20O21
1922.38
10.60
+2
-3.63
1.394
Evidence Records 16 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
195 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 195 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024
Evidence 3 Activity

Activity

85±17.9% Cell death
Toxicity
256 µg/mL
Cytotoxic
85±17.9% Cell death | 256 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024
Evidence 4 Activity

Activity

50% Cell death
Toxicity
121 µg/mL
Cytotoxic
50% Cell death | 121 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024
Evidence 5 Activity

Activity

IC50
Toxicity
40.35 µM
Cytotoxic
IC50 | 40.35 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog. | Peptides | 2012
Evidence 6 Activity

Activity

53% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
53% Hemolysis | 100 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog. | Peptides | 2012
Evidence 7 Activity

Activity

52% Hemolysis
Toxicity
80 µM
Hemolytic Cytotoxic
52% Hemolysis | 80 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog. | Peptides | 2012
Evidence 8 Activity

Activity

51% Hemolysis
Toxicity
60 µM
Hemolytic Cytotoxic
51% Hemolysis | 60 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog. | Peptides | 2012
Evidence 9 Activity

Activity

45% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
45% Hemolysis | 40 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog. | Peptides | 2012
Evidence 10 Activity

Activity

27% Hemolysis
Toxicity
20 µM
Hemolytic Cytotoxic
27% Hemolysis | 20 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog. | Peptides | 2012
Evidence 11 Activity

Activity

18% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
18% Hemolysis | 10 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog. | Peptides | 2012
Evidence 12 Activity

Activity

10% Hemolysis
Toxicity
45 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 45 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024
Evidence 13 Activity

Activity

50% Hemolysis
Toxicity
112 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 112 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024
Evidence 14 Activity

Activity

97.6±12.6% Cell death
Toxicity
256 µg/mL
Cytotoxic
97.6±12.6% Cell death | 256 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024
Evidence 15 Activity

Activity

50% Cell death
Toxicity
59.3 µg/mL
Cytotoxic
50% Cell death | 59.3 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024
Evidence 16 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis