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Peptide record

TPDB08926

buCATHL4C(CAT) Antibacterial Antifungal Cell-penetrating Peptides Toxicity Tumor-homing Peptides standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08926
buCATHL4C(CAT)
Antibacterial Antifungal Cell-penetrating Peptides Toxicity Tumor-homing Peptides
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia Antifungipept CPPsite3.0 ToxinPred 3.0 TumorHoPe2.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Antifungal, Cell-penetrating Peptides, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
RIRFPWPWRWPWWRRVRG
Physicochemical Analysis
C128H177N41O19
ANDCEQHLKMSTY
R
2594.08
13.10
6
0
8
+6
-4.40
-1.400
37.78
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
27500
1060.11
0
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
0
L
0
K
0
M
1
F
3
P
0
S
0
T
5
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 0 M: 0 F: 1 P: 3 S: 0 T: 0 W: 5 Y: 0 V: 1
Chemical Descriptors
18
C128H177N41O19
2594.08
13.10
+6
-4.40
-1.400
Free
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)O
Evidence Records 5 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, Smmc‐7721, A549, Nci‐H460 Cell Lines And Lo‐2, Hek293, 293T, And Mrc‐5 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
EGFP and MAP 30 protein
Cytoplasm
EGFP‐CAT 2‐8‐times higher intensity than other derivative and 3‐6 times higher than EGFP‐LL37, EGFP‐IL, EGFP‐L‐K6, and EGFP‐TAT
Endocytosis
In vitro
CCSSSCSSSSSSSTTCCC
Evidence 2 Activity

Activity

85% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
85% Hemolysis | 150 | µM | target cell: Buffalo erythrocytes

Target

Buffalo erythrocytes

Source & Reference

NA
DBAASP
Diversity, Antimicrobial Action and Structure-Activity Relationship of Buffalo Cathelicidins. | PLoS One | 2015
Evidence 3 Activity

Activity

45% Hemolysis
Toxicity
60 µM
Hemolytic Cytotoxic
45% Hemolysis | 60 | µM | target cell: Buffalo erythrocytes

Target

Buffalo erythrocytes

Source & Reference

NA
DBAASP
Diversity, Antimicrobial Action and Structure-Activity Relationship of Buffalo Cathelicidins. | PLoS One | 2015
Evidence 4 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Liver cancer, Cervical cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Screening and characterization of a novel high-efficiency tumor-homing cell-penetrating peptide from the buffalo cathelicidin family
2019
Xu Y Y et al. J Pept Sci. 2019 Sep 25(9):e3201

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Human Cervical Tumor cell line HeLa, Human Hepatoma cell line SMMC‐7721, Human Non‐Small‐Cell Lung Tumor cell line A549, carcinoma cell line NCI‐H460, Human Embryonic Lung cell line MRC‐5
Synthetic
Evidence 5 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing

Source & Reference

TumorHoPe2.0
TumorHoPe2
Screening and characterization of a novel high-efficiency tumor-homing cell-penetrating peptide from the buffalo cathelicidin family
2019
Xu Y et al. J Pept Sci. 2019 Sep 25(9):e3201.

Other

SMMC‐7721, A549, NCI‐H460, MRC‐7, LO‐2, HEK293, 293T, MRC-5
Synthetic
FITC, Enhanced Green Fluorescent Protein(EGFP), Momordica charantia‐derived type‐I RIP(MAP 30)
cell penetrating peptide
Additional Detail Fields 3 fields
FITC, Enhanced Green Fluorescent Protein(EGFP), Momordica charantia‐derived type‐I RIP(MAP 30)
CCSSSCSSSSSSSTTCCC
Human Cervical Tumor cell line HeLa, Human Hepatoma cell line SMMC‐7721, Human Non‐Small‐Cell Lung Tumor cell line A549, carcinoma cell line NCI‐H460, Human Embryonic Lung cell line MRC‐5 SMMC‐7721, A549, NCI‐H460, MRC‐7, LO‐2, HEK293, 293T, MRC-5