TPDB

3D PDB MODEL

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TPDB ID TPDB08925

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 18-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.

Sequence

RGGRLTYTRPRFTVTVGR

FASTA

>TPDB08925|Antibacterial;Toxicity|length=18
RGGRLTYTRPRFTVTVGR

Formula C91H153N33O24

Absent Amino Acids ANDCEQHIKMSW

Common Amino Acids R

Mass 2093.42

PI 12.58

Basic Residues 5

Acidic Residues 0

Hydrophobic Residues 5

Net Charge +5

Boman Index 2.60

Hydrophobicity -0.800

Aliphatic Index 53.89

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 71.18

Polar Residues 5

number

0

A

5

R

0

N

0

D

0

C

0

E

0

Q

3

G

0

H

0

I

1

L

0

K

0

M

1

F

1

P

0

S

4

T

0

W

1

Y

2

V

Amino Acid Distribution

A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 1 S: 0 T: 4 W: 0 Y: 1 V: 2

Length

18

Formula

C91H153N33O24

Mass

2093.42

PI

12.58

Net Charge

+5

Boman Index

2.60

Hydrophobicity

-0.800

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.3 µg/mL

Target

Target Organism Escherichia coli JM109

Source & Reference

Database Source NA

Other

Evidence Text

active against E. coli JM109 (MIC 6.3 ug/ml), B. subtilis BR151 (MIC 25 ug/ml), penicillin-resistant S. aureus 1206 (MIC 50 ug/ml), an

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µg/mL

Target

Target Organism B. subtilis BR151

Source & Reference

Database Source NA

Other

Evidence Text

active against E. coli JM109 (MIC 6.3 ug/ml), B. subtilis BR151 (MIC 25 ug/ml), penicillin-resistant S. aureus 1206 (MIC 50 ug/ml), and vancomycin-resistant E. faecium

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µg/mL

Target

Target Organism Staphylococcus aureus 1206

Source & Reference

Database Source NA

Other

Evidence Text

nst E. coli JM109 (MIC 6.3 ug/ml), B. subtilis BR151 (MIC 25 ug/ml), penicillin-resistant S. aureus 1206 (MIC 50 ug/ml), and vancomycin-resistant E. faecium A634 (MIC 12.5-25 ug/ml) (Anti-VRE).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12.5-25 µg/mL

Target

Target Organism E. faecium A634

Source & Reference

Database Source NA

Other

Evidence Text

C 25 ug/ml), penicillin-resistant S. aureus 1206 (MIC 50 ug/ml), and vancomycin-resistant E. faecium A634 (MIC 12.5-25 ug/ml) (Anti-VRE).