TPDB

3D PDB MODEL

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TPDB ID TPDB08924

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 18-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.

Sequence

RGGRLCYTRPRFTVCVGR

FASTA

>TPDB08924|Antibacterial;Toxicity|length=18
RGGRLCYTRPRFTVCVGR

Formula C89H149N33O22S2

Absent Amino Acids ANDEQHIKMSW

Common Amino Acids R

Mass 2097.49

PI 11.81

Basic Residues 5

Acidic Residues 0

Hydrophobic Residues 5

Net Charge +5

Boman Index 1.84

Hydrophobicity -0.444

Aliphatic Index 53.89

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 1615

Absorbance 280nm 77.00

Polar Residues 5

number

0

A

5

R

0

N

0

D

2

C

0

E

0

Q

3

G

0

H

0

I

1

L

0

K

0

M

1

F

1

P

0

S

2

T

0

W

1

Y

2

V

Amino Acid Distribution

A: 0 R: 5 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 1 S: 0 T: 2 W: 0 Y: 1 V: 2

Length

18

Formula

C89H149N33O22S2

Mass

2097.49

PI

11.81

Net Charge

+5

Boman Index

1.84

Hydrophobicity

-0.444

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.3 µg/mL

Target

Target Organism Escherichia coli JM109

Source & Reference

Database Source NA

Other

Evidence Text

active against E. coli JM109 (MIC 6.3 ug/ml), B. subtilis BR151 (MIC 3.1 ug/ml), penicillin-resistant S. aureus 1206 (MIC 12.5 ug/ml),

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.1 µg/mL

Target

Target Organism B. subtilis BR151

Source & Reference

Database Source NA

Other

Evidence Text

active against E. coli JM109 (MIC 6.3 ug/ml), B. subtilis BR151 (MIC 3.1 ug/ml), penicillin-resistant S. aureus 1206 (MIC 12.5 ug/ml), and vancomycin-resistant E. faeciu

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12.5 µg/mL

Target

Target Organism Staphylococcus aureus 1206

Source & Reference

Database Source NA

Other

Evidence Text

st E. coli JM109 (MIC 6.3 ug/ml), B. subtilis BR151 (MIC 3.1 ug/ml), penicillin-resistant S. aureus 1206 (MIC 12.5 ug/ml), and vancomycin-resistant E. faecium A634 (MIC 3.1 ug/ml) anti-VRE.

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.1 µg/mL

Target

Target Organism E. faecium A634

Source & Reference

Database Source NA

Other

Evidence Text

.1 ug/ml), penicillin-resistant S. aureus 1206 (MIC 12.5 ug/ml), and vancomycin-resistant E. faecium A634 (MIC 3.1 ug/ml) anti-VRE.