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Peptide record

TPDB08923

Antibacterial Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08923
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Hemolytic2 PD_Hemolysis
standard
No
A 18-aa standard-residue multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Hemolytic2, and other sources, with an available 3D structural model.
Sequence
RDAKELVELFFEEIRRAL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C101H164N28O29
NCQGHMPSTWY
E
2234.58
4.79
4
5
9
-1
2.94
-0.311
113.89
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
2
A
3
R
0
N
1
D
0
C
4
E
0
Q
0
G
0
H
1
I
3
L
1
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 3 N: 0 D: 1 C: 0 E: 4 Q: 0 G: 0 H: 0 I: 1 L: 3 K: 1 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
18 reviewed residue count
C101H164N28O29 sequence-only estimate (linear, free termini)
2234.58 sequence-only estimate (linear, free termini)
4.79 sequence-only estimate (linear, free termini)
-1 sequence-only estimate (linear, free termini)
2.94 sequence-only estimate (linear, free termini)
-0.311 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

46% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
46% Hemolysis | 10 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Amphipathic alpha-helices in proteins: results from analysis of protein structures. | Proteins | 2005
Evidence 2 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis