Back to search

Peptide record

TPDB08915

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB08915
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia SATPdb Antifungipept CAFPdb dbAMP 3.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
KWKKLLKKPLLKKLLKKL
Physicochemical Analysis
C112H204N28O19
ARNDCEQGHIMFSTYV
K
2247.03
11.41
9
0
8
+9
3.59
-0.611
151.67
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
244.77
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
7
L
9
K
0
M
0
F
1
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 7 K: 9 M: 0 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
18
C112H204N28O19
2247.03
11.41
+9
3.59
-0.611
Evidence Records 17 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.13 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against Gram- P. aeruginosa ATCC 27853 (MIC 3.13 uM), A. baumannii KCTC 2508 (MIC1.56 uM), Gram+ S. aureus ATCC 25923 (MIC 1.56 uM), and B. su
Evidence 2 Activity

Activity

MIC
Antibacterial
1.56 µM

Target

A. baumannii KCTC 2508

Source & Reference

dbAMP

Other

active against Gram- P. aeruginosa ATCC 27853 (MIC 3.13 uM), A. baumannii KCTC 2508 (MIC1.56 uM), Gram+ S. aureus ATCC 25923 (MIC 1.56 uM), and B. subtilis KCTC 2217 (MIC 1.56 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
1.56 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP

Other

Gram- P. aeruginosa ATCC 27853 (MIC 3.13 uM), A. baumannii KCTC 2508 (MIC1.56 uM), Gram+ S. aureus ATCC 25923 (MIC 1.56 uM), and B. subtilis KCTC 2217 (MIC 1.56 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
1.56 µM

Target

B. subtilis KCTC 2217

Source & Reference

dbAMP

Other

3 uM), A. baumannii KCTC 2508 (MIC1.56 uM), Gram+ S. aureus ATCC 25923 (MIC 1.56 uM), and B. subtilis KCTC 2217 (MIC 1.56 uM).
Evidence 5 Activity

Activity

MIC
Antifungal
3.13 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against Gram- P. aeruginosa ATCC 27853 (MIC 3.13 uM), A. baumannii KCTC 2508 (MIC1.56 uM), Gram+ S. aureus ATCC 25923 (MIC 1.56 uM), and B. su
Evidence 6 Activity

Activity

MIC
Antifungal
1.56 µM

Target

A. baumannii KCTC 2508

Source & Reference

dbAMP CAFPdb Antifungipept

Other

active against Gram- P. aeruginosa ATCC 27853 (MIC 3.13 uM), A. baumannii KCTC 2508 (MIC1.56 uM), Gram+ S. aureus ATCC 25923 (MIC 1.56 uM), and B. subtilis KCTC 2217 (MIC 1.56 uM).
Evidence 7 Activity

Activity

MIC
Antifungal
1.56 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Gram- P. aeruginosa ATCC 27853 (MIC 3.13 uM), A. baumannii KCTC 2508 (MIC1.56 uM), Gram+ S. aureus ATCC 25923 (MIC 1.56 uM), and B. subtilis KCTC 2217 (MIC 1.56 uM).
Evidence 8 Activity

Activity

MIC
Antifungal
1.56 µM

Target

B. subtilis KCTC 2217

Source & Reference

dbAMP CAFPdb Antifungipept

Other

3 uM), A. baumannii KCTC 2508 (MIC1.56 uM), Gram+ S. aureus ATCC 25923 (MIC 1.56 uM), and B. subtilis KCTC 2217 (MIC 1.56 uM).
Evidence 9 Activity

Activity

MIC
Antiparasitic
3.13 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
active against Gram- P. aeruginosa ATCC 27853 (MIC 3.13 uM), A. baumannii KCTC 2508 (MIC1.56 uM), Gram+ S. aureus ATCC 25923 (MIC 1.56 uM), and B. su
Evidence 10 Activity

Activity

MIC
Antiparasitic
1.56 µM

Target

A. baumannii KCTC 2508

Source & Reference

dbAMP 3.0

Other

active against Gram- P. aeruginosa ATCC 27853 (MIC 3.13 uM), A. baumannii KCTC 2508 (MIC1.56 uM), Gram+ S. aureus ATCC 25923 (MIC 1.56 uM), and B. subtilis KCTC 2217 (MIC 1.56 uM).
Evidence 11 Activity

Activity

MIC
Antiparasitic
1.56 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP 3.0

Other

Gram- P. aeruginosa ATCC 27853 (MIC 3.13 uM), A. baumannii KCTC 2508 (MIC1.56 uM), Gram+ S. aureus ATCC 25923 (MIC 1.56 uM), and B. subtilis KCTC 2217 (MIC 1.56 uM).
Evidence 12 Activity

Activity

MIC
Antiparasitic
1.56 µM

Target

B. subtilis KCTC 2217

Source & Reference

dbAMP 3.0

Other

3 uM), A. baumannii KCTC 2508 (MIC1.56 uM), Gram+ S. aureus ATCC 25923 (MIC 1.56 uM), and B. subtilis KCTC 2217 (MIC 1.56 uM).
Evidence 13 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibiotic activity of Leu-Lys rich model peptides. | Biotechnol Lett | 2003
Evidence 14 Activity

Activity

14% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
14% Hemolysis | 100 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Mechanism of action of antimicrobial peptide P5 truncations against Pseudomonas aeruginosa and Staphylococcus aureus | AMB Express | 2019
Evidence 15 Activity

Activity

70% Killing
Toxicity
100 µM
Cytotoxic
70% Killing | 100 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Mechanism of action of antimicrobial peptide P5 truncations against Pseudomonas aeruginosa and Staphylococcus aureus | AMB Express | 2019
Evidence 16 Activity

Activity

5% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
5% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Potent antimicrobial peptides with selectivity for Bacillus anthracis over human erythrocytes. | Int J Antimicrob Agents | 2011
Evidence 17 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Antimicrob Agents. 2011 Sep 38(3):237-42.