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Peptide record

TPDB08904

Antibacterial Antifungal Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08904
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 DRAMP Peptipedia Antifungipept CAFPdb dbAMP HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GLLGPLLKIAAKVGSKLL
Physicochemical Analysis
C85H155N21O20
RNDCEQHMFTWY
L
1791.29
10.84
3
0
10
+3
-0.36
1.100
178.89
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
1
I
6
L
3
K
0
M
0
F
1
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 6 K: 3 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
18
C85H155N21O20
1791.29
10.84
+3
-0.36
1.100
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
80 µM
Hemolytic Cytotoxic
50% Hemolysis | 80 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of potent, non-toxic antimicrobial agents based upon the naturally occurring frog skin peptides, ascaphin-8 and peptide XT-7. | Chem Biol Drug Des | 2008
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
142 µM
Hemolytic Cytotoxic
50% Hemolysis | 142 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Improving the selectivity of antimicrobial peptides from anuran skin. | J Chem Inf Model | 2012
Evidence 3 Activity

Activity

LC50
Toxicity
80 µM
Hemolytic
Hemolytic_activity: [Ref.23094651]50% hemolysis against rat erythrocytes at 142 µM.##[Ref.18554256]Hemolysis against human erythrocytes (LC50=80 µM).

Target

erythrocytes

Source & Reference

NA
DRAMP
J Chem Inf Model. 2012 Dec 21 52(12):3341-51.##Chem Biol Drug Des. 2008 Jul 72(1):58-64.
Evidence 4 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis