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Peptide record

TPDB08900

Antibacterial Antifungal Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08900
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 DRAMP Peptipedia Antifungipept CAFPdb dbAMP HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GLLGKLLKIAAKVGKKLL
Physicochemical Analysis
C89H167N23O19
RNDCEQHMFPSTWY
L
1863.45
11.12
5
0
10
+5
1.04
0.800
178.89
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
1
I
6
L
5
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 6 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
18
C89H167N23O19
1863.45
11.12
+5
1.04
0.800
Evidence Records 4 records
Evidence 1 Activity

Activity

LC50
Hemolysis
25 µM
[Ref.18554256]Hemolysis against human erythrocytes (LC50=25 µM).

Target

human erythrocytes

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Chem Biol Drug Des. 2008 Jul 72(1):58-64.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
50% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of potent, non-toxic antimicrobial agents based upon the naturally occurring frog skin peptides, ascaphin-8 and peptide XT-7. | Chem Biol Drug Des | 2008
Evidence 3 Activity

Activity

LC50
Toxicity
25 µM
Hemolytic
Hemolytic_activity: [Ref.18554256]Hemolysis against human erythrocytes (LC50=25 µM).

Target

erythrocytes

Source & Reference

NA
DRAMP
Chem Biol Drug Des. 2008 Jul 72(1):58-64.
Evidence 4 Hemolysis

Activity

25 µM
LC50
[Ref.18554256]Hemolysis against human erythrocytes (LC50=25 µM).
Hemolysis

Target

human erythrocytes

Source & Reference

HemoPI PD_Hemolysis
Chem Biol Drug Des. 2008 Jul 72(1):58-64.
DRAMP4
PD_Hemolysis