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Peptide record

TPDB08892

Antibacterial Antifungal Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08892
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic PD_Hemolysis ToxinPred 3.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLKGCWTKWYSLKPKCPF
Physicochemical Analysis
C110H158N24O22S2
ARNDEQHIMV
K
2232.73
9.98
4
0
7
+4
-3.36
-0.311
43.33
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
12615
565.00
5
Residue Composition
number
0
A
0
R
0
N
0
D
2
C
0
E
0
Q
1
G
0
H
0
I
2
L
4
K
0
M
2
F
2
P
1
S
1
T
2
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 4 M: 0 F: 2 P: 2 S: 1 T: 1 W: 2 Y: 1 V: 0
Chemical Descriptors
18
C110H158N24O22S2
2232.73
9.98
+4
-3.36
-0.311
Evidence Records 21 records
Evidence 1 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

Escherichia coli ATCC25922

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli ATCC25922 (MIC 25 ug/ml), B. dysenteriae (MIC 3 ug/ml), S. aureus ATCC2592 (MIC 6.25 ug/ml), B. subtilis ATCC 6633
Evidence 2 Activity

Activity

MIC
Antibacterial
3 µg/mL

Target

B. dysenteriae

Source & Reference

dbAMP DRAMP

Other

Active against E. coli ATCC25922 (MIC 25 ug/ml), B. dysenteriae (MIC 3 ug/ml), S. aureus ATCC2592 (MIC 6.25 ug/ml), B. subtilis ATCC 6633 (MIC 3 ug/ml), and C. albican
Evidence 3 Activity

Activity

MIC
Antibacterial
6.25 µg/mL

Target

Staphylococcus aureus ATCC2592

Source & Reference

dbAMP DRAMP

Other

Active against E. coli ATCC25922 (MIC 25 ug/ml), B. dysenteriae (MIC 3 ug/ml), S. aureus ATCC2592 (MIC 6.25 ug/ml), B. subtilis ATCC 6633 (MIC 3 ug/ml), and C. albicans ATCC2002 (MIC 50 ug/ml).
Evidence 4 Activity

Activity

MIC
Antibacterial
3 µg/mL

Target

B. subtilis ATCC 6633

Source & Reference

dbAMP DRAMP

Other

C25922 (MIC 25 ug/ml), B. dysenteriae (MIC 3 ug/ml), S. aureus ATCC2592 (MIC 6.25 ug/ml), B. subtilis ATCC 6633 (MIC 3 ug/ml), and C. albicans ATCC2002 (MIC 50 ug/ml).
Evidence 5 Activity

Activity

MIC
Antibacterial
50 µg/mL

Target

Candida albicans ATCC2002

Source & Reference

dbAMP DRAMP

Other

C 3 ug/ml), S. aureus ATCC2592 (MIC 6.25 ug/ml), B. subtilis ATCC 6633 (MIC 3 ug/ml), and C. albicans ATCC2002 (MIC 50 ug/ml).
Evidence 6 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

Escherichia coli ATCC25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli ATCC25922 (MIC 25 ug/ml), B. dysenteriae (MIC 3 ug/ml), S. aureus ATCC2592 (MIC 6.25 ug/ml), B. subtilis ATCC 6633
Evidence 7 Activity

Activity

MIC
Antifungal
3 µg/mL

Target

B. dysenteriae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli ATCC25922 (MIC 25 ug/ml), B. dysenteriae (MIC 3 ug/ml), S. aureus ATCC2592 (MIC 6.25 ug/ml), B. subtilis ATCC 6633 (MIC 3 ug/ml), and C. albican
Evidence 8 Activity

Activity

MIC
Antifungal
6.25 µg/mL

Target

Staphylococcus aureus ATCC2592

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli ATCC25922 (MIC 25 ug/ml), B. dysenteriae (MIC 3 ug/ml), S. aureus ATCC2592 (MIC 6.25 ug/ml), B. subtilis ATCC 6633 (MIC 3 ug/ml), and C. albicans ATCC2002 (MIC 50 ug/ml).
Evidence 9 Activity

Activity

MIC
Antifungal
3 µg/mL

Target

B. subtilis ATCC 6633

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

C25922 (MIC 25 ug/ml), B. dysenteriae (MIC 3 ug/ml), S. aureus ATCC2592 (MIC 6.25 ug/ml), B. subtilis ATCC 6633 (MIC 3 ug/ml), and C. albicans ATCC2002 (MIC 50 ug/ml).
Evidence 10 Activity

Activity

MIC
Antifungal
50 µg/mL

Target

Candida albicans ATCC2002

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

C 3 ug/ml), S. aureus ATCC2592 (MIC 6.25 ug/ml), B. subtilis ATCC 6633 (MIC 3 ug/ml), and C. albicans ATCC2002 (MIC 50 ug/ml).
Evidence 11 Activity

Activity

% Hemolysis
Hemolysis
2.3 5.6 18.7 29.5 3.1 7.3 20.5 32.9 %
[Ref.27114317] Human red blood cells: 2.3% hemolysis at 25µg/ml 5.6% hemolysis at 50µg/ml 18.7% hemolysis at 100µg/ml 29.5% hemolysis at 200µg/ml. Rabbit red blood cells :3.1% hemolysis at 25µg/ml 7.3% hemolysis at 50µg/ml 20.5% hemolysis at 100µg/ml 32.9% hemolysis at 200µg/ml

Target

Human red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Chin J Nat Med. 2016 Apr 14(4):294-298.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 12 Activity

Activity

2% Hemolysis
Toxicity
25 µg/mL
Hemolytic Cytotoxic
2% Hemolysis | 25 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Two novel antimicrobial peptides from skin venoms of spadefoot toad Megophrys minor. | Chin J Nat Med | 2016
Evidence 13 Activity

Activity

6% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
6% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Two novel antimicrobial peptides from skin venoms of spadefoot toad Megophrys minor. | Chin J Nat Med | 2016
Evidence 14 Activity

Activity

19% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
19% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Two novel antimicrobial peptides from skin venoms of spadefoot toad Megophrys minor. | Chin J Nat Med | 2016
Evidence 15 Activity

Activity

30% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
30% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Two novel antimicrobial peptides from skin venoms of spadefoot toad Megophrys minor. | Chin J Nat Med | 2016
Evidence 16 Activity

Activity

3% Hemolysis
Toxicity
25 µg/mL
Hemolytic Cytotoxic
3% Hemolysis | 25 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Two novel antimicrobial peptides from skin venoms of spadefoot toad Megophrys minor. | Chin J Nat Med | 2016
Evidence 17 Activity

Activity

7% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
7% Hemolysis | 50 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Two novel antimicrobial peptides from skin venoms of spadefoot toad Megophrys minor. | Chin J Nat Med | 2016
Evidence 18 Activity

Activity

21% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
21% Hemolysis | 100 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Two novel antimicrobial peptides from skin venoms of spadefoot toad Megophrys minor. | Chin J Nat Med | 2016
Evidence 19 Activity

Activity

33% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
33% Hemolysis | 200 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Two novel antimicrobial peptides from skin venoms of spadefoot toad Megophrys minor. | Chin J Nat Med | 2016
Evidence 20 Activity

Activity

% Hemolysis
Toxicity
2.3 %
Hemolytic
Hemolytic_activity: [Ref.27114317] Human red blood cells: 2.3% hemolysis at 25µg/ml 5.6% hemolysis at 50µg/ml 18.7% hemolysis at 100µg/ml 29.5% hemolysis at 200µg/ml. Rabbit red blood cells :3.1% hemolysis at 25µg/ml 7.3% hemolysis at 50µg/ml 20.5% hemolysis at 100µg/ml 32.9% hemolysis at 200µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
Chin J Nat Med. 2016 Apr 14(4):294-298.
Evidence 21 Hemolysis

Activity

2.3 5.6 18.7 29.5 3.1 7.3 20.5 32.9 %
% Hemolysis
[Ref.27114317] Human red blood cells: 2.3% hemolysis at 25µg/ml 5.6% hemolysis at 50µg/ml 18.7% hemolysis at 100µg/ml 29.5% hemolysis at 200µg/ml. Rabbit red blood cells :3.1% hemolysis at 25µg/ml 7.3% hemolysis at 50µg/ml 20.5% hemolysis at 100µg/ml 32.9% hemolysis at 200µg/ml
Hemolysis

Target

Human red blood cells

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
Chin J Nat Med. 2016 Apr 14(4):294-298.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.