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Peptide record

TPDB08878

Antibacterial Antifungal Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08878
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KWCRCVCRRGICRCRCRK
Physicochemical Analysis
C90H161N39O19S6
ANDEQHLMFPSTY
RC
2285.88
10.56
8
0
3
+8
3.32
-0.689
37.78
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5875
257.01
6
Residue Composition
number
0
A
6
R
0
N
0
D
6
C
0
E
0
Q
1
G
0
H
1
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 6 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
18
C90H161N39O19S6
2285.88
10.56
+8
3.32
-0.689
Evidence Records 2 records
Evidence 1 Activity

Activity

25% Hemolysis
Toxicity
3900 µM
Hemolytic Cytotoxic
25% Hemolysis | 3900 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Marked increase in membranolytic selectivity of novel cyclic tachyplesins constrained with an antiparallel two-beta strand cystine knot framework. | Biochem Biophys Res Commun | 2000
Evidence 2 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.10673369] EC25=3900 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem Biophys Res Commun. 2000 Jan 27 267(3):783-90.