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Peptide record

TPDB08877

Antibacterial Antifungal Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08877
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 18-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KWCRCVCRRGICRCRCRG
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C86H152N38O19S6
ANDEQHLMFPSTY
RC
2214.76
10.15
7
0
3
+7
4.12
-0.494
37.78
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5875
2.65
6
Residue Composition
number
0
A
6
R
0
N
0
D
6
C
0
E
0
Q
2
G
0
H
1
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 6 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
18 reviewed residue count
C86H152N38O19S6 sequence-only estimate (linear, free termini)
2214.76 sequence-only estimate (linear, free termini)
10.15 sequence-only estimate (linear, free termini)
+7 sequence-only estimate (linear, free termini)
4.12 sequence-only estimate (linear, free termini)
-0.494 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

25% Hemolysis
Toxicity
920 µM
Hemolytic Cytotoxic
25% Hemolysis | 920 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Marked increase in membranolytic selectivity of novel cyclic tachyplesins constrained with an antiparallel two-beta strand cystine knot framework. | Biochem Biophys Res Commun | 2000
Evidence 2 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.10673369] EC25=920 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem Biophys Res Commun. 2000 Jan 27 267(3):783-90.