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Peptide record

TPDB08873

Antibacterial Cell-penetrating Peptides Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08873
Antibacterial Cell-penetrating Peptides Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Cell-penetrating Peptides, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, CellPPD, and other sources, with an available 3D structural model.
Sequence
KLALKAAAKAWKAAAKAA
Physicochemical Analysis
C83H144N24O19
RNDCEQGHIMFPSTYV
A
1782.21
11.12
5
0
13
+5
0.28
0.289
98.89
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
308.61
0
Residue Composition
number
10
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
5
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 10 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
18
C83H144N24O19
1782.21
11.12
+5
0.28
0.289
Evidence Records 1 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>200 µM
Hemolytic Cytotoxic
50% Hemolysis | >200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Hydrophobicity, hydrophobic moment and angle subtended by charged residues modulate antibacterial and haemolytic activity of amphipathic helical peptides | FEBS Lett | 1997