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Peptide record

TPDB08842

Alpha-amylase (150-167) Amyl (1-18) Antibacterial Anticancer Antifungal Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08842
Alpha-amylase (150-167) Amyl (1-18)
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb DBAASP
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
HLNKRVQRELIGWLDWLK
Physicochemical Analysis
C107H170N32O25
ACMFPSTY
L
2304.73
10.57
5
2
8
+2
2.64
-0.683
124.44
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
11000
477.28
2
Residue Composition
number
0
A
2
R
1
N
1
D
0
C
1
E
1
Q
1
G
1
H
1
I
4
L
2
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 1 D: 1 C: 0 E: 1 Q: 1 G: 1 H: 1 I: 1 L: 4 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 1
Chemical Descriptors
18
C107H170N32O25
2304.73
10.57
+2
2.64
-0.683
Evidence Records 3 records
Evidence 1 Activity

Activity

1% Hemolysis
Toxicity
500 µM
Hemolytic Cytotoxic
1% Hemolysis | 500 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity and mechanism of action of a novel cationic ?-helical octadecapeptide derived from ?-amylase of rice. | Biopolymers | 2015
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
0.1 %
Hemolytic
Hemolytic_activity: [Ref.27478151] 0.1% hemolysis at 100 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biosci Bioeng. 2016 Dec 122(6):652-659. doi: 10.1016/j.jbiosc.2016.05.008. ##Biopolymers. 2016 Mar 106(2):219-229. doi: 10.1002/bip.22817.
Evidence 3 Activity

Target

Cutibacterium acnes

Source & Reference

DBAASP