Back to search

Peptide record

TPDB08829

Antibacterial Anticancer Antifungal Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB08829
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CancerPPD 2.0 dbACP dbAMP 3.0 AFP-GFuse CAFPdb
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GCRRLCWRQRCVTWCRGR
Physicochemical Analysis
C94H155N39O21S4
ANDEHIKMFPSY
R
2295.75
11.71
6
0
4
+6
0.45
-0.878
37.78
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11250
490.04
6
Residue Composition
number
0
A
6
R
0
N
0
D
4
C
0
E
1
Q
2
G
0
H
0
I
1
L
0
K
0
M
0
F
0
P
0
S
1
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 4 E: 0 Q: 1 G: 2 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 1 W: 2 Y: 0 V: 1
Chemical Descriptors
18
C94H155N39O21S4
2295.75
11.71
+6
0.45
-0.878
Evidence Records 3 records
Evidence 1 Activity

Activity

45.9±3.9% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
45.9±3.9% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. | ACS Chem Biol | 2017
Evidence 2 Activity

Activity

CC50
Toxicity
31.3±2.6 µM
Cytotoxic
CC50 | 31.3±2.6 | µM | target cell: Human foreskin fibroblasts (HFF)

Target

Human foreskin fibroblasts (HFF)

Source & Reference

NA
DBAASP
Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. | ACS Chem Biol | 2017
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
49.8 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.28741926] 42-49.8% hemolysis at 64 µM against human red blood cells | Cytotoxicity: [Ref.28741926] CC50 = 31.6 ± 1.3 µM against CRL-1739, CC50 = 5.4 ± 0.3 µM against MM96L, CC50 = 31.3 ± 2.6 µM against HFF-1, CC50 = 41.0 ± 4.2 µM against HeLa, CC50 = 15.1 ± 1.4 µM against MCF-7, CC50 = 3.9 ± 0.1 µM against K-562.

Target

erythrocytes

Source & Reference

NA
DRAMP
ACS Chem Biol. 2017 Sep 15 12(9):2324-2334. doi: 10.1021/acschembio.7b00459.?