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Peptide record

TPDB08827

Antibacterial Anticancer Antifungal Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08827
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CancerPPD 2.0 dbACP dbAMP 3.0 Antifungipept CAFPdb
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GCRALCYKQRCVTYCRGA
Physicochemical Analysis
C84H139N29O23S4
NDEHIMFPSW
C
2051.45
9.17
4
0
6
+4
0.49
-0.189
48.89
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3230
157.45
8
Residue Composition
number
2
A
3
R
0
N
0
D
4
C
0
E
1
Q
2
G
0
H
0
I
1
L
1
K
0
M
0
F
0
P
0
S
1
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 2 R: 3 N: 0 D: 0 C: 4 E: 0 Q: 1 G: 2 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 2 V: 1
Chemical Descriptors
18
C84H139N29O23S4
2051.45
9.17
+4
0.49
-0.189
Evidence Records 4 records
Evidence 1 Activity

Activity

39.3±9.3% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
39.3±9.3% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. | ACS Chem Biol | 2017
Evidence 2 Activity

Activity

CC50
Toxicity
51.2±4.0 µM
Cytotoxic
CC50 | 51.2±4.0 | µM | target cell: Human foreskin fibroblasts (HFF)

Target

Human foreskin fibroblasts (HFF)

Source & Reference

NA
DBAASP
Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. | ACS Chem Biol | 2017
Evidence 3 Activity

Activity

CC50
Toxicity
30.8±2.5 µM
Cytotoxic
CC50 | 30.8±2.5 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. | ACS Chem Biol | 2017
Evidence 4 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.28741926] 0% hemolysis at 17 µM , 3% hemolysis at 35 µM , 30-48.6% hemolysis at 64 µM , 40% hemolysis at 100 µM against human red blood cells | Cytotoxicity: [Ref.28741926] CC50 > 64 µM against CRL-1739, CC50 = 10.3 ± 1.1 µM against MM96L, CC50 = 51.2 ± 4.0 µM against HFF-1, CC50 > 64 µM against HeLa, CC50 = 48.4 ± 0.7 µM against MCF-7, CC50 = 11.5 ± 0.6 µM against K-562, CC50 = 34.1 ± 3.9 µM against HL-60 CC50=30.8 ± 2.5µM against PBMCs.

Target

erythrocytes

Source & Reference

NA
DRAMP
ACS Chem Biol. 2017 Sep 15 12(9):2324-2334. doi: 10.1021/acschembio.7b00459.?