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Peptide record

TPDB08806

Antibacterial Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08806
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 18-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
KLALKLALKAWKLALKAA
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C95H168N24O19
RNDCEQGHIMFPSTYV
AL
1950.53
11.12
5
0
13
+5
-0.83
0.733
163.33
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
2.82
0
Residue Composition
number
6
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
6
L
5
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 6 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 6 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
18 reviewed residue count
C95H168N24O19 sequence-only estimate (linear, free termini)
1950.53 sequence-only estimate (linear, free termini)
11.12 sequence-only estimate (linear, free termini)
+5 sequence-only estimate (linear, free termini)
-0.83 sequence-only estimate (linear, free termini)
0.733 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

100% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
100% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cyclic antimicrobial R-, W-rich peptides: the role of peptide structure and E. coli outer and inner membranes in activity and the mode of action. | Eur Biophys J | 2011