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Peptide record

TPDB08800

Antibacterial Antifungal Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08800
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP PD_Hemolysis
standard
No
A 18-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
YKLLKKLLKKLKKLLKKL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C111H207N27O20
ARNDCEQGHIMFPSTWV
K
2240.03
11.08
9
0
9
+9
0.60
-0.333
173.33
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
0.67
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
8
L
9
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 8 K: 9 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
18 reviewed residue count
C111H207N27O20 sequence-only estimate (linear, free termini)
2240.03 sequence-only estimate (linear, free termini)
11.08 sequence-only estimate (linear, free termini)
+9 sequence-only estimate (linear, free termini)
0.60 sequence-only estimate (linear, free termini)
-0.333 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
6.1 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 6.1 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Rapid identification of compounds with enhanced antimicrobial activity by using conformationally defined combinatorial libraries. | Biochem J | 1996
Evidence 2 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis