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Peptide record

TPDB08797

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08797
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb PD_Hemolysis
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
WLRAFRRLVRRLARGLRR
Physicochemical Analysis
C105H183N43O19
NDCEQHIKMPSTY
R
2351.88
13.25
8
0
9
+8
1.00
-0.639
113.89
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
233.85
0
Residue Composition
number
2
A
8
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
4
L
0
K
0
M
1
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 8 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 4 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
18
C105H183N43O19
2351.88
13.25
+8
1.00
-0.639
Evidence Records 4 records
Evidence 1 Activity

Activity

MHC10
Hemolysis
27.22 µM
[Ref.28002968] MHC10=27.22 µM against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
J Med Chem. 2016 Dec 22 59(24):10946-10962. doi: 10.1021/acs.jmedchem.6b00922.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

10% Hemolysis
Toxicity
27.22 µM
Hemolytic Cytotoxic
10% Hemolysis | 27.22 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles. | J Med Chem | 2016
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.28002968] MHC10=27.22 µM against human red blood cells | Cytotoxicity: [Ref.28002968] The cell viability of RAW264.7 cells induced by WRL3 is 98.31%, 95.21%, 92.96%, 90.70%, 89.30%, 89.01%, 76.90%, 48.45% and 40.73% at peptide concentrations of 0.25, 0.5, 1, 2, 4, 8, 16, 32 and 64 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
J Med Chem. 2016 Dec 22 59(24):10946-10962. doi: 10.1021/acs.jmedchem.6b00922.
Evidence 4 Hemolysis

Activity

27.22 µM
MHC10
[Ref.28002968] MHC10=27.22 µM against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

PD_Hemolysis
J Med Chem. 2016 Dec 22 59(24):10946-10962. doi: 10.1021/acs.jmedchem.6b00922.
DRAMP4
PD_Hemolysis