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Peptide record

TPDB08783

Antibacterial Anticancer Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08783
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CancerPPD 2.0 dbACP
standard
No
A 18-aa standard-residue multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
SKVWRHWRRFWHRAHRLH
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C119H171N45O20
NDCEQGIMPTY
R
2551.96
13.00
10
0
7
+6
4.53
-1.672
43.33
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
16500
6.47
1
Residue Composition
number
1
A
5
R
0
N
0
D
0
C
0
E
0
Q
0
G
4
H
0
I
1
L
1
K
0
M
1
F
0
P
1
S
0
T
3
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 4 I: 0 L: 1 K: 1 M: 0 F: 1 P: 0 S: 1 T: 0 W: 3 Y: 0 V: 1
Chemical Descriptors
18 reviewed residue count
C119H171N45O20 sequence-only estimate (linear, free termini)
2551.96 sequence-only estimate (linear, free termini)
13.00 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
4.53 sequence-only estimate (linear, free termini)
-1.672 sequence-only estimate (linear, free termini)
Evidence Records 11 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.13 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against S. aureus (MIC 3.13 uM), S. epidermidis MRSE1208 (MIC 12.5 uM), B. cereus (MIC 3.13 uM), S. lactis (MIC 3.13 uM),
Evidence 2 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Staphylococcus epidermidis MRSE1208

Source & Reference

dbAMP DRAMP

Other

active against S. aureus (MIC 3.13 uM), S. epidermidis MRSE1208 (MIC 12.5 uM), B. cereus (MIC 3.13 uM), S. lactis (MIC 3.13 uM), E. faecalis (MIC 1.56 uM), E. faecium
Evidence 3 Activity

Activity

MIC
Antibacterial
3.13 µM

Target

B. cereus

Source & Reference

dbAMP DRAMP

Other

active against S. aureus (MIC 3.13 uM), S. epidermidis MRSE1208 (MIC 12.5 uM), B. cereus (MIC 3.13 uM), S. lactis (MIC 3.13 uM), E. faecalis (MIC 1.56 uM), E. faecium (MIC 3.13 uM), E. coli (M
Evidence 4 Activity

Activity

MIC
Antibacterial
3.13 µM

Target

S. lactis

Source & Reference

dbAMP DRAMP

Other

S. aureus (MIC 3.13 uM), S. epidermidis MRSE1208 (MIC 12.5 uM), B. cereus (MIC 3.13 uM), S. lactis (MIC 3.13 uM), E. faecalis (MIC 1.56 uM), E. faecium (MIC 3.13 uM), E. coli (MIC 6.25 uM), E-cloacae (M
Evidence 5 Activity

Activity

MIC
Antibacterial
1.56 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP DRAMP

Other

S. epidermidis MRSE1208 (MIC 12.5 uM), B. cereus (MIC 3.13 uM), S. lactis (MIC 3.13 uM), E. faecalis (MIC 1.56 uM), E. faecium (MIC 3.13 uM), E. coli (MIC 6.25 uM), E-cloacae (MIC >50 uM), P-fluorescens M
Evidence 6 Activity

Activity

MIC
Antibacterial
3.13 µM

Target

E. faecium

Source & Reference

dbAMP DRAMP

Other

IC 12.5 uM), B. cereus (MIC 3.13 uM), S. lactis (MIC 3.13 uM), E. faecalis (MIC 1.56 uM), E. faecium (MIC 3.13 uM), E. coli (MIC 6.25 uM), E-cloacae (MIC >50 uM), P-fluorescens MRPF0322 (MIC >50 uM), and
Evidence 7 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

C 3.13 uM), S. lactis (MIC 3.13 uM), E. faecalis (MIC 1.56 uM), E. faecium (MIC 3.13 uM), E. coli (MIC 6.25 uM), E-cloacae (MIC >50 uM), P-fluorescens MRPF0322 (MIC >50 uM), and P. aeruginosa (MIC 1.56
Evidence 8 Activity

Activity

MIC
Antibacterial
1.56 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

, E. coli (MIC 6.25 uM), E-cloacae (MIC >50 uM), P-fluorescens MRPF0322 (MIC >50 uM), and P. aeruginosa (MIC 1.56 uM). It can neutralize LPS and reducing inflammation ( Li et al., 2023 ).
Evidence 9 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity analysis and biological studies of chensinin-1b analogues | Acta Biomater | 2016
Evidence 10 Activity

Activity

50% Hemolysis
Toxicity
>500 µM
Hemolytic Cytotoxic
50% Hemolysis | >500 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity and membrane interaction mechanism of the antimicrobial peptides derived from Rana chensinensis with short sequences | Biologia | 2017
Evidence 11 Activity

Activity

HC50
Toxicity
500 µM
Hemolytic
Hemolytic_activity: [Ref.27060618] HC50>500µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Acta Biomater. 2016 Jun 37:59-68.