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Peptide record

TPDB08777

Antibacterial Anticancer Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08777
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RWKIFKKIPKFLHSAKKF
Physicochemical Analysis
C115H180N30O20
NDCEQGMTYV
K
2302.88
11.90
8
0
8
+7
1.70
-0.633
70.56
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
238.83
1
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
2
I
1
L
6
K
0
M
3
F
1
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 2 L: 1 K: 6 M: 0 F: 3 P: 1 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
18
C115H180N30O20
2302.88
11.90
+7
1.70
-0.633
Evidence Records 3 records
Evidence 1 Activity

Activity

2% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
2% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Peptoid-Substituted Hybrid Antimicrobial Peptide Derived from Papiliocin and Magainin 2 with Enhanced Bacterial Selectivity and Anti-inflammatory Activity. | Biochemistry | 2015
Evidence 2 Activity

Activity

50% Cell death
Toxicity
9 µM
Cytotoxic
50% Cell death | 9 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Peptoid-Substituted Hybrid Antimicrobial Peptide Derived from Papiliocin and Magainin 2 with Enhanced Bacterial Selectivity and Anti-inflammatory Activity. | Biochemistry | 2015
Evidence 3 Activity

Activity

MHC
Toxicity
100 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.26053120] MHC=100 µM against human red blood cells | Cytotoxicity: [Ref.26053120] IC50 = 10 µM against mouse macrophage-derived RAW264.7 cells. ##IC50 = 9 µM for NIH3T3 fibroblasts.

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochemistry. 2015 Jun 30 54(25):3921-31. doi: 10.1021/acs.biochem.5b00392.