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Peptide record

TPDB08772

Antibacterial Anticancer Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08772
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia dbACP ToxinPred 3.0
standard
No
A 18-aa standard-residue multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, dbACP, and other sources, with an available 3D structural model.
Sequence
RRGCFRVCYRGFCFQRCR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C98H153N37O21S4
ANDEHILKMPSTW
R
2313.77
10.92
6
0
5
+6
4.18
-0.556
16.11
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1740
0.75
6
Residue Composition
number
0
A
6
R
0
N
0
D
4
C
0
E
1
Q
2
G
0
H
0
I
0
L
0
K
0
M
3
F
0
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 4 E: 0 Q: 1 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 3 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
18 reviewed residue count
C98H153N37O21S4 sequence-only estimate (linear, free termini)
2313.77 sequence-only estimate (linear, free termini)
10.92 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
4.18 sequence-only estimate (linear, free termini)
-0.556 sequence-only estimate (linear, free termini)
Evidence Records 5 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
46 µM
Hemolytic Cytotoxic
50% Hemolysis | 46 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cytotoxic Potential of the Novel Horseshoe Crab Peptide Polyphemusin III. | Mar Drugs | 2018
Evidence 2 Activity

Activity

IC50
Toxicity
7.3±0.4 µM
Cytotoxic
IC50 | 7.3±0.4 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Cytotoxic Potential of the Novel Horseshoe Crab Peptide Polyphemusin III. | Mar Drugs | 2018
Evidence 3 Activity

Activity

IC50
Toxicity
7±0.4 µM
Cytotoxic
IC50 | 7±0.4 | µM | target cell: Human embryonic fibroblasts

Target

Human embryonic fibroblasts

Source & Reference

NA
DBAASP
Cytotoxic Potential of the Novel Horseshoe Crab Peptide Polyphemusin III. | Mar Drugs | 2018
Evidence 4 Activity

Activity

IC50
Toxicity
7.5±0.5 µM
Cytotoxic
IC50 | 7.5±0.5 | µM | target cell: Human normal astrocytes

Target

Human normal astrocytes

Source & Reference

NA
DBAASP
Cytotoxic Potential of the Novel Horseshoe Crab Peptide Polyphemusin III. | Mar Drugs | 2018
Evidence 5 Activity

Activity

HC50
Toxicity
46 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human red blood cells (hBRC): HC50=46 µM | Cytotoxicity: HEK 293T: IC50=7.3±0.4 µM HEF: IC50=7.0±0.4 µM NHA: IC50=7.5±0.5 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Mar Drugs. 2018 Nov 26 16(12):466.