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Peptide record

TPDB08769

Antibacterial Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08769
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 18-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RKYVRFLHRWVKYFRAYL
Physicochemical Analysis
C123H181N35O22
NDCEQGIMPST
R
2502.01
11.41
7
0
11
+6
-1.90
-0.578
81.11
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
9970
398.48
3
Residue Composition
number
1
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
0
I
2
L
2
K
0
M
2
F
0
P
0
S
0
T
1
W
3
Y
2
V
Amino Acid Distribution
A: 1 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 2 K: 2 M: 0 F: 2 P: 0 S: 0 T: 0 W: 1 Y: 3 V: 2
Chemical Descriptors
18
C123H181N35O22
2502.01
11.41
+6
-1.90
-0.578
Evidence Records 4 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
87.5 µM
Hemolytic Cytotoxic
0% Hemolysis | 87.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Adevonin, a novel synthetic antimicrobial peptide designed from the Adenanthera pavonina trypsin inhibitor (ApTI) sequence. | Pathog Glob Health | 2018
Evidence 2 Activity

Activity

75% Hemolysis
Toxicity
175 µM
Hemolytic Cytotoxic
75% Hemolysis | 175 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Adevonin, a novel synthetic antimicrobial peptide designed from the Adenanthera pavonina trypsin inhibitor (ApTI) sequence. | Pathog Glob Health | 2018
Evidence 3 Activity

Activity

25% Killing
Toxicity
10 µM
Cytotoxic
25% Killing | 10 | µM | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Adevonin, a novel synthetic antimicrobial peptide designed from the Adenanthera pavonina trypsin inhibitor (ApTI) sequence. | Pathog Glob Health | 2018
Evidence 4 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.30570384] 0% hemolysis at 43.75 µM , 72.5% hemolysis at 175 µM , 77% hemolysis at 350 µg/ml against human type O erythrocytes | Cytotoxicity: [Ref.30570384] In fibroblasts, a significant reduction of cell viability, of 25% on average, is observed in each time interval(24,48 and 72h) in the highest peptide concentration(10 µM)

Target

erythrocytes

Source & Reference

NA
DRAMP
Pathog Glob Health.?2018 Dec 112(8):438-447. doi: 10.1080/20477724.2018.1559489.