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Peptide record

TPDB08768

Antibacterial Antifungal Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08768
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RKKTRKRLKKIGKVLKWI
Physicochemical Analysis
C106H195N35O20
ANDCEQHMFPSY
K
2279.94
12.73
10
0
6
+10
5.99
-1.222
102.78
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
241.23
1
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
2
L
7
K
0
M
0
F
0
P
0
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 2 K: 7 M: 0 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
18
C106H195N35O20
2279.94
12.73
+10
5.99
-1.222
Evidence Records 2 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
5% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity, improved cell selectivity and mode of action of short PMAP-36-derived peptides against bacteria and Candida. | Sci Rep | 2016
Evidence 2 Activity

Activity

MHC
Toxicity
128 µM
Hemolytic
Hemolytic_activity: [Ref.27251456] 5% hemolysis at 128 µM, MHC=128 µM against human red blood cells.

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Rep. 2016 Jun 2 6:27258.