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Peptide record

TPDB08766

Antibacterial Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08766
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 DRAMP Peptipedia
standard
No
A 18-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, DRAMP, and Peptipedia, with an available 3D structural model.
Sequence
RIVQRIKKWLLKWKKLGY
Physicochemical Analysis
C115H190N32O21
ANDCEHMFPST
K
2356.98
11.70
7
0
9
+7
0.29
-0.606
124.44
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
12490
529.92
2
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
2
I
3
L
5
K
0
M
0
F
0
P
0
S
0
T
2
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 2 L: 3 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 1 V: 1
Chemical Descriptors
18
C115H190N32O21
2356.98
11.70
+7
0.29
-0.606
Evidence Records 2 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
160 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 160 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of de novo designed cationic peptides against multi-resistant clinical isolates. | Eur J Med Chem | 2014
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic
Hemolytic_activity: [Ref.31778756]P5 displayed less than 10% hemolysis in all the range tested (0-1024 µg/mL)

Target

erythrocytes

Source & Reference

NA
DRAMP
Microb Pathog. 2020 Feb 139:103886. doi: 10.1016/j.micpath.2019.103886. Epub 2019 Nov 25.