TPDB

3D PDB MODEL

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TPDB ID TPDB08762

Activity

Antibacterial Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP

Sequence_Type

standard

Has_Modification No

Description A 18-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.

Sequence

NLVSALIEGRKYLKNVLK

FASTA

>TPDB08762|Antibacterial;Antifungal;Toxicity|length=18
NLVSALIEGRKYLKNVLK

Formula C94H164N26O25

Absent Amino Acids DCQHMFPTW

Common Amino Acids L

Mass 2058.50

PI 10.46

Basic Residues 4

Acidic Residues 1

Hydrophobic Residues 9

Net Charge +3

Boman Index 3.26

Hydrophobicity 0.039

Aliphatic Index 146.11

Half Life

Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 72.38

Polar Residues 4

number

1

A

1

R

2

N

0

D

0

C

1

E

0

Q

1

G

0

H

1

I

4

L

3

K

0

M

0

F

0

P

1

S

0

T

0

W

1

Y

2

V

Amino Acid Distribution

A: 1 R: 1 N: 2 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 1 L: 4 K: 3 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 2

Length

18

Formula

C94H164N26O25

Mass

2058.50

PI

10.46

Net Charge

+3

Boman Index

3.26

Hydrophobicity

0.039

Evidence 1 Activity

Activity

Activity Endpoint 8% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

8% Hemolysis | 128 | µg/mL | target cell: Horse erythrocytes

Target

Target Cell Horse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Discovery of Distinctin-Like-Peptide-PH (DLP-PH) From the Skin Secretion of Phyllomedusa hypochondrialis, a Prototype of a Novel Family of Antimicrobial Peptide. | Front Microbiol | 2018

Evidence 2 Activity

Activity

Activity Endpoint 20% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 256 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

20% Hemolysis | 256 | µg/mL | target cell: Horse erythrocytes

Target

Target Cell Horse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Discovery of Distinctin-Like-Peptide-PH (DLP-PH) From the Skin Secretion of Phyllomedusa hypochondrialis, a Prototype of a Novel Family of Antimicrobial Peptide. | Front Microbiol | 2018

Evidence 3 Activity

Activity

Activity Endpoint 40% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 512 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

40% Hemolysis | 512 | µg/mL | target cell: Horse erythrocytes

Target

Target Cell Horse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Discovery of Distinctin-Like-Peptide-PH (DLP-PH) From the Skin Secretion of Phyllomedusa hypochondrialis, a Prototype of a Novel Family of Antimicrobial Peptide. | Front Microbiol | 2018