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Peptide record

TPDB08756

Antibacterial Anticancer Antifungal Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08756
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
WGRAFSRGVRRLARGGRG
Physicochemical Analysis
C86H143N37O20
NDCEQHIKMPTY
R
2015.32
13.10
6
0
6
+6
1.23
-0.906
48.89
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
272.91
1
Residue Composition
number
2
A
6
R
0
N
0
D
0
C
0
E
0
Q
5
G
0
H
0
I
1
L
0
K
0
M
1
F
0
P
1
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 5 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
18
C86H143N37O20
2015.32
13.10
+6
1.23
-0.906
Evidence Records 2 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
>63.54 µM
Hemolytic Cytotoxic
10% Hemolysis | >63.54 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles. | J Med Chem | 2016
Evidence 2 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.28002968] MHC10>63.54 µM against human red blood cells | Cytotoxicity: [Ref.28002968] The cell viability of RAW264.7 cells induced by WR5 is 98.59%, 97.46%, 96.06%, 96.09%, 92.96%, 91.83%, 89.58%, 87.32% and 85.48% at peptide concentrations of 0.25, 0.5, 1, 2, 4, 8, 16, 32 and 64 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
J Med Chem. 2016 Dec 22 59(24):10946-10962. doi: 10.1021/acs.jmedchem.6b00922.