Back to search

Peptide record

TPDB08735

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB08735
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CancerPPD 2.0 dbACP dbAMP 3.0 AFP-GFuse Antifungipept CAFPdb
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GCRRLCYKQRCVTYCRGR
Physicochemical Analysis
C90H153N35O23S4
ANDEHIMFPSW
R
2221.67
10.10
6
0
4
+6
2.45
-0.889
37.78
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3230
145.39
8
Residue Composition
number
0
A
5
R
0
N
0
D
4
C
0
E
1
Q
2
G
0
H
0
I
1
L
1
K
0
M
0
F
0
P
0
S
1
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 4 E: 0 Q: 1 G: 2 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 2 V: 1
Chemical Descriptors
18
C90H153N35O23S4
2221.67
10.10
+6
2.45
-0.889
Evidence Records 4 records
Evidence 1 Activity

Activity

45.9±9.4% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
45.9±9.4% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. | ACS Chem Biol | 2017
Evidence 2 Activity

Activity

CC50
Toxicity
71.7±9.2 µM
Cytotoxic
CC50 | 71.7±9.2 | µM | target cell: Human foreskin fibroblasts (HFF)

Target

Human foreskin fibroblasts (HFF)

Source & Reference

NA
DBAASP
Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. | ACS Chem Biol | 2017
Evidence 3 Activity

Activity

CC50
Toxicity
10.8±0.8 µM
Cytotoxic
CC50 | 10.8±0.8 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. | ACS Chem Biol | 2017
Evidence 4 Activity

Activity

% Hemolysis
Toxicity
5 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.28741926] 5% hemolysis at 0.03 µM , 0% hemolysis at 1.1 µM , 10% hemolysis at 17 µM , 50% hemolysis at 100µM against human red blood cells | Cytotoxicity: [Ref.28741926] CC50 = 39.8 ± 1.0 µM against CRL-1739, CC50 = 2.9 ± 0.1 µM against MM96L, CC50 = 71.7 ± 9.2 µM against HFF-1, CC50 > 64 µM against HeLa, CC50 = 15.3 ± 1.4 µM against MCF-7, CC50 = 2.7 ± 0.1 µM against K-562, CC50 = 12.7 ± 1.1 µM PBMCs.

Target

erythrocytes

Source & Reference

NA
DRAMP
ACS Chem Biol. 2017 Sep 15 12(9):2324-2334. doi: 10.1021/acschembio.7b00459.?