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Peptide record

TPDB08719

Antibacterial Antifungal Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08719
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia Antifungipept CAFPdb APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 18-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
FLFSLIPSAISGLINAFK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C95H148N20O23
RDCEQHMTWYV
ILFS
1938.34
10.10
1
0
11
+1
-1.15
1.394
141.11
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
4
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
3
I
3
L
1
K
0
M
3
F
1
P
3
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 3 K: 1 M: 0 F: 3 P: 1 S: 3 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18 reviewed residue count
C95H148N20O23 sequence-only estimate (linear, free termini)
1938.34 sequence-only estimate (linear, free termini)
10.10 sequence-only estimate (linear, free termini)
+1 sequence-only estimate (linear, free termini)
-1.15 sequence-only estimate (linear, free termini)
1.394 sequence-only estimate (linear, free termini)
Evidence Records 4 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram+ and Gram- bacteria. Active against B. cereus CGMCC 1.1846 (LC 19.57 uM), B. megaterium CGMCC 1.0459 (lethal concentration LC 2.67 uM), B. subtilis CGMCC 1.2428 (LC 4.01 uM), M. luteus CGMCC 1.0290 (LC 1.50 uM), methicillin-sensitive S. aureus CGMCC 1.89 (LC 3.14 uM), penicillin-sensitive S. epidermidi P1111 (LC 4.77 uM), methicillin-resistant coagulase-negative S. aureus p1369 (LC 3.88 uM), MRSA P1374 (LC 3.61 uM), penicillin-resistant S. epidermidis P1389 (LC 3.52 uM), MRSA p1386 (LC 5.13 uM), PRSE P1389 (LC 5.13 uM), S. aureus J685 (LC 5.36 uM), S. aureus J698 (LC 4.11 uM), S. aureus J700 (LC 8.44 uM), S. aureus J706 (LC 7.049 uM), S. aureus J708 (LC 6.21 uM), S. aureus J710 (LC 7.04 uM), S. sanguinis ATCC 1.2497 (LC 2.7 uM), S. salivarius ATCC 1.2498 (LC 5.36 uM), S. mutans ATCC 1.2499 (LC 5.23 uM), S. warneri ATCC 1.2824 (LC 8.65 uM), and SSCA CGMCC 4.1765 (LC 7.75 uM).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram+ and Gram- bacteria. Active against B. cereus CGMCC 1.1846 (LC 19.57 uM), B. megaterium CGMCC 1.0459 (lethal concentration LC 2.67 uM), B. subtilis CGMCC 1.2428 (LC 4.01 uM), M. luteus CGMCC 1.0290 (LC 1.50 uM), methicillin-sensitive S. aureus CGMCC 1.89 (LC 3.14 uM), penicillin-sensitive S. epidermidi P1111 (LC 4.77 uM), methicillin-resistant coagulase-negative S. aureus p1369 (LC 3.88 uM), MRSA P1374 (LC 3.61 uM), penicillin-resistant S. epidermidis P1389 (LC 3.52 uM), MRSA p1386 (LC 5.13 uM), PRSE P1389 (LC 5.13 uM), S. aureus J685 (LC 5.36 uM), S. aureus J698 (LC 4.11 uM), S. aureus J700 (LC 8.44 uM), S. aureus J706 (LC 7.049 uM), S. aureus J708 (LC 6.21 uM), S. aureus J710 (LC 7.04 uM), S. sanguinis ATCC 1.2497 (LC 2.7 uM), S. salivarius ATCC 1.2498 (LC 5.36 uM), S. mutans ATCC 1.2499 (LC 5.23 uM), S. warneri ATCC 1.2824 (LC 8.65 uM), and SSCA CGMCC 4.1765 (LC 7.75 uM).
Evidence 3 Activity

Activity

100% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
100% Hemolysis | 12.5 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Mesobuthus Venom-Derived Antimicrobial Peptides Possess Intrinsic Multifunctionality and Differential Potential as Drugs. | Front Microbiol | 2018
Evidence 4 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.