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Peptide record

TPDB08717

Antibacterial Antifungal Antiparasitic Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08717
Antibacterial Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 DRAMP Peptipedia Antifungipept CAFPdb dbAMP dbAMP 3.0 i2APP APD_complete APD_hemolytic PD_Hemolysis
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
NLLGSLLKTGLKVGSNLL
Physicochemical Analysis
C83H150N22O24
ARDCEQHIMFPWY
L
1840.24
10.60
2
0
8
+2
-0.60
0.694
167.78
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
0
0.00
5
Residue Composition
number
0
A
0
R
2
N
0
D
0
C
0
E
0
Q
3
G
0
H
0
I
7
L
2
K
0
M
0
F
0
P
2
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 7 K: 2 M: 0 F: 0 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
18
C83H150N22O24
1840.24
10.60
+2
-0.60
0.694
Evidence Records 20 records
Evidence 1 Activity

Activity

MIC
Antibacterial
128 µM

Target

E.coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
DRAMP antibacterial activity supported by MIC records against bacterial target organisms. dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram- E.coli (MIC 128 uM), P.aeruginosa (MIC >256 uM), Gram+ S. aureus (MIC 32 uM), M. luteus (MIC 2 uM), yeast S.
Evidence 2 Activity

Activity

MIC
Antibacterial
>256 µM

Target

P.aeruginosa

Source & Reference

dbAMP DRAMP

Other

Active against Gram- E.coli (MIC 128 uM), P.aeruginosa (MIC >256 uM), Gram+ S. aureus (MIC 32 uM), M. luteus (MIC 2 uM), yeast S. cerevisiae (MIC 64 uM), and
Evidence 3 Activity

Activity

MIC
Antibacterial
32 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Active against Gram- E.coli (MIC 128 uM), P.aeruginosa (MIC >256 uM), Gram+ S. aureus (MIC 32 uM), M. luteus (MIC 2 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC95 2-26
Evidence 4 Activity

Activity

MIC
Antibacterial
2 µM

Target

M. luteus

Source & Reference

dbAMP DRAMP

Other

ainst Gram- E.coli (MIC 128 uM), P.aeruginosa (MIC >256 uM), Gram+ S. aureus (MIC 32 uM), M. luteus (MIC 2 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC95 2-264 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
64 µM

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP

Other

uM), P.aeruginosa (MIC >256 uM), Gram+ S. aureus (MIC 32 uM), M. luteus (MIC 2 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC95 2-264 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
128 µM

Target

E.coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
DRAMP antifungal activity supported by activity records against fungal target organisms. dbAMP classified under the Anti-fungal function class.
Active against Gram- E.coli (MIC 128 uM), P.aeruginosa (MIC >256 uM), Gram+ S. aureus (MIC 32 uM), M. luteus (MIC 2 uM), yeast S.
Evidence 7 Activity

Activity

MIC
Antifungal
>256 µM

Target

P.aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram- E.coli (MIC 128 uM), P.aeruginosa (MIC >256 uM), Gram+ S. aureus (MIC 32 uM), M. luteus (MIC 2 uM), yeast S. cerevisiae (MIC 64 uM), and
Evidence 8 Activity

Activity

MIC
Antifungal
32 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram- E.coli (MIC 128 uM), P.aeruginosa (MIC >256 uM), Gram+ S. aureus (MIC 32 uM), M. luteus (MIC 2 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC95 2-26
Evidence 9 Activity

Activity

MIC
Antifungal
2 µM

Target

M. luteus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ainst Gram- E.coli (MIC 128 uM), P.aeruginosa (MIC >256 uM), Gram+ S. aureus (MIC 32 uM), M. luteus (MIC 2 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC95 2-264 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
64 µM

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM), P.aeruginosa (MIC >256 uM), Gram+ S. aureus (MIC 32 uM), M. luteus (MIC 2 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC95 2-264 uM).
Evidence 11 Activity

Activity

MIC
Antiparasitic
128 µM

Target

E.coli

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against Gram- E.coli (MIC 128 uM), P.aeruginosa (MIC >256 uM), Gram+ S. aureus (MIC 32 uM), M. luteus (MIC 2 uM), yeast S.
Evidence 12 Activity

Activity

MIC
Antiparasitic
>256 µM

Target

P.aeruginosa

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against Gram- E.coli (MIC 128 uM), P.aeruginosa (MIC >256 uM), Gram+ S. aureus (MIC 32 uM), M. luteus (MIC 2 uM), yeast S. cerevisiae (MIC 64 uM), and
Evidence 13 Activity

Activity

MIC
Antiparasitic
32 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against Gram- E.coli (MIC 128 uM), P.aeruginosa (MIC >256 uM), Gram+ S. aureus (MIC 32 uM), M. luteus (MIC 2 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC95 2-26
Evidence 14 Activity

Activity

MIC
Antiparasitic
2 µM

Target

M. luteus

Source & Reference

dbAMP 3.0 DRAMP

Other

ainst Gram- E.coli (MIC 128 uM), P.aeruginosa (MIC >256 uM), Gram+ S. aureus (MIC 32 uM), M. luteus (MIC 2 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC95 2-264 uM).
Evidence 15 Activity

Activity

MIC
Antiparasitic
64 µM

Target

S. cerevisiae

Source & Reference

dbAMP 3.0 DRAMP

Other

uM), P.aeruginosa (MIC >256 uM), Gram+ S. aureus (MIC 32 uM), M. luteus (MIC 2 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC95 2-264 uM).
Evidence 16 Activity

Activity

50% Hemolysis
Toxicity
256 µM
Hemolytic Cytotoxic
50% Hemolysis | 256 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Origin and functional diversification of an amphibian defense peptide arsenal. | PLoS Genet | 2013
Evidence 17 Activity

Activity

IC50
Toxicity
128 µM
Cytotoxic
IC50 | 128 | µM | target cell: Mouse splenocytes

Target

Mouse splenocytes

Source & Reference

NA
DBAASP
Origin and functional diversification of an amphibian defense peptide arsenal. | PLoS Genet | 2013
Evidence 18 Activity

Activity

0% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
0% Hemolysis | 50 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Physicochemical and biological characterizations of Pxt peptides from amphibian (Xenopus tropicalis) skin. | J Biochem | 2016
Evidence 19 Activity

Activity

IC50
Toxicity
256 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.26802742]0% Hemolysis against Rat erythrocytes at 50 µM.##[Ref.23935531]Hemolysis against Mouse erythrocytes(IC50=256 µM). | Cytotoxicity: [Ref.23935531]Cytotoxicity against T-lymphocytes(IC50=128 µM).

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biochem. 2016 Jun 159(6):619-29.##PLoS Genet. 2013 9(8):e1003662.
Evidence 20 Hemolysis

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.