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Peptide record

TPDB08716

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08716
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KIGAKIKIGAKIKIGAKI
Physicochemical Analysis
C87H164N24O19
RNDCEQHLMFPSTWYV
IK
1850.41
11.21
6
0
9
+6
3.60
0.433
146.67
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
3
A
0
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
6
I
0
L
6
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 6 L: 0 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C87H164N24O19
1850.41
11.21
+6
3.60
0.433
Evidence Records 5 records
Evidence 1 Activity

Activity

3% Hemolysis
Toxicity
500 µg/mL
Hemolytic Cytotoxic
3% Hemolysis | 500 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A novel linear amphipathic beta-sheet cationic antimicrobial peptide with enhanced selectivity for bacterial lipids | J Biol Chem | 2001
Evidence 2 Activity

Activity

14% Hemolysis
Toxicity
7.5 µM
Hemolytic Cytotoxic
14% Hemolysis | 7.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Stereochemical effects on the aggregation and biological properties of the fibril-forming peptide [KIGAKI]3 in membranes. | Phys Chem Chem Phys | 2013
Evidence 3 Activity

Activity

54% Hemolysis
Toxicity
60 µM
Hemolytic Cytotoxic
54% Hemolysis | 60 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Stereochemical effects on the aggregation and biological properties of the fibril-forming peptide [KIGAKI]3 in membranes. | Phys Chem Chem Phys | 2013
Evidence 4 Activity

Activity

1% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
1% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterisation and evaluation of synthetic antimicrobial peptides against Bacillus globigii, Bacillus anthracis and Burkholderia thailandensis. | Int J Antimicrob Agents | 2010
Evidence 5 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis