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Peptide record

TPDB08701

Antibacterial Anticancer Antifungal Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08701
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CancerPPD 2.0 dbACP dbAMP 3.0 Antifungipept CAFPdb
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KCRRLCYRQRCVTYCRGR
Physicochemical Analysis
C94H162N38O23S4
ANDEHIMFPSW
R
2320.80
10.57
7
0
4
+7
3.25
-1.117
37.78
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
3230
139.18
8
Residue Composition
number
0
A
6
R
0
N
0
D
4
C
0
E
1
Q
1
G
0
H
0
I
1
L
1
K
0
M
0
F
0
P
0
S
1
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 4 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 2 V: 1
Chemical Descriptors
18
C94H162N38O23S4
2320.80
10.57
+7
3.25
-1.117
Evidence Records 4 records
Evidence 1 Activity

Activity

CC50
Toxicity
9.0±0.5 µM
Cytotoxic
CC50 | 9.0±0.5 | µM | target cell: Human foreskin fibroblasts (HFF)

Target

Human foreskin fibroblasts (HFF)

Source & Reference

NA
DBAASP
Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. | ACS Chem Biol | 2017
Evidence 2 Activity

Activity

CC50
Toxicity
5.1±0.3 µM
Cytotoxic
CC50 | 5.1±0.3 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. | ACS Chem Biol | 2017
Evidence 3 Activity

Activity

45.1±11.8% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
45.1±11.8% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. | ACS Chem Biol | 2017
Evidence 4 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.28741926] 0% hemolysis at 0.5 µM , 2.5% hemolysis at 0.6 µM , 20% hemolysis at 8 µM , 43.3-56.9% hemolysis at 64 µM , 50% hemolysis at 100 µM against human red blood cells | Cytotoxicity: [Ref.28741926] CC50 = 19.5 ± 0.5 µM against CRL-1739, CC50 = 1.7 ± 0.1 µM against MM96L, CC50 = 9.0 ± 0.5 µM against HFF-1, CC50 = 44.2 ± 2.2µM against HeLa, CC50 = 6.7 ± 0.7 µM against MCF-7, CC50 = 2.1 ± 0.2 µM against K-562, CC50 = 9.0 ± 1.1µM against HL-60 CC50=5.1 ± 0.3µM against PBMCs.

Target

erythrocytes

Source & Reference

NA
DRAMP
ACS Chem Biol. 2017 Sep 15 12(9):2324-2334. doi: 10.1021/acschembio.7b00459.?