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Peptide record

TPDB08695

Antibacterial Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08695
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 18-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
GKLGPLLKIAAKVGSKLL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C85H156N22O20
RNDCEQHMFTWY
L
1806.31
11.00
4
0
9
+4
-0.80
0.672
157.22
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
1
I
5
L
4
K
0
M
0
F
1
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 5 K: 4 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
18 reviewed residue count
C85H156N22O20 sequence-only estimate (linear, free termini)
1806.31 sequence-only estimate (linear, free termini)
11.00 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
-0.80 sequence-only estimate (linear, free termini)
0.672 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>800 µM
Hemolytic Cytotoxic
50% Hemolysis | >800 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Improving the selectivity of antimicrobial peptides from anuran skin. | J Chem Inf Model | 2012