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Peptide record

TPDB08694

Antibacterial Anticancer Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08694
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CancerPPD 2.0 dbACP dbAMP 3.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GCRRWCYKQRCVTYCRGR
Physicochemical Analysis
C95H152N36O23S4
ANDEHILMFPS
R
2294.72
10.10
6
0
4
+6
1.16
-1.150
16.11
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
8730
380.44
8
Residue Composition
number
0
A
5
R
0
N
0
D
4
C
0
E
1
Q
2
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
1
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 4 E: 0 Q: 1 G: 2 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 2 V: 1
Chemical Descriptors
18
C95H152N36O23S4
2294.72
10.10
+6
1.16
-1.150
Evidence Records 3 records
Evidence 1 Activity

Activity

40.1±3.3% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
40.1±3.3% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. | ACS Chem Biol | 2017
Evidence 2 Activity

Activity

CC50
Toxicity
25.0±2.9 µM
Cytotoxic
CC50 | 25.0±2.9 | µM | target cell: Human foreskin fibroblasts (HFF)

Target

Human foreskin fibroblasts (HFF)

Source & Reference

NA
DBAASP
Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. | ACS Chem Biol | 2017
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
43.4 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.28741926] 36.8-43.4% hemolysis at 64 µM against human red blood cells | Cytotoxicity: [Ref.28741926] CC50 = 18.3 ± 1.4 µM against CRL-1739, CC50 = 4.0 ± 0.1 µM against MM96L, CC50 = 25.0 ± 2.9 µM against HFF-1, CC50 = 17.1 ± 0.7 µM against HeLa, CC50 = 1.0 ± 0.1 µM against K-562.

Target

erythrocytes

Source & Reference

NA
DRAMP
ACS Chem Biol. 2017 Sep 15 12(9):2324-2334. doi: 10.1021/acschembio.7b00459.?