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Peptide record

TPDB08693

Antibacterial Anticancer Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08693
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CancerPPD 2.0 dbACP dbAMP 3.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GCRRLCYRQRCVTYCRGR
Physicochemical Analysis
C90H153N37O23S4
ANDEHIKMFPSW
R
2249.68
10.26
6
0
4
+6
2.27
-0.922
37.78
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3230
143.58
8
Residue Composition
number
0
A
6
R
0
N
0
D
4
C
0
E
1
Q
2
G
0
H
0
I
1
L
0
K
0
M
0
F
0
P
0
S
1
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 4 E: 0 Q: 1 G: 2 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 2 V: 1
Chemical Descriptors
18
C90H153N37O23S4
2249.68
10.26
+6
2.27
-0.922
Evidence Records 3 records
Evidence 1 Activity

Activity

CC50
Toxicity
34.5±3.6 µM
Cytotoxic
CC50 | 34.5±3.6 | µM | target cell: Human foreskin fibroblasts (HFF)

Target

Human foreskin fibroblasts (HFF)

Source & Reference

NA
DBAASP
Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. | ACS Chem Biol | 2017
Evidence 2 Activity

Activity

44.8±10.0% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
44.8±10.0% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. | ACS Chem Biol | 2017
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
54.8 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.28741926] 34.8-54.8% hemolysis at 64 µM against human red blood cells | Cytotoxicity: [Ref.28741926] CC50 = 29.4 ± 1.1 µM against CRL-1739, CC50 = 5.0 ± 0.3 µM against MM96L, CC50 = 34.5 ± 3.6 µM against HFF-1, CC50 = 39.4 ± 2.6 µM against HeLa, CC50 = 3.1 ± 0.1 µM against K-562.

Target

erythrocytes

Source & Reference

NA
DRAMP
ACS Chem Biol. 2017 Sep 15 12(9):2324-2334. doi: 10.1021/acschembio.7b00459.?