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Peptide record

TPDB08684

Antibacterial Anticancer Antifungal Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08684
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia SATPdb dbACP Antifungipept CAFPdb dbAMP
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, SATPdb, and other sources, with an available 3D structural model.
Sequence
GKKLKKIGQKIKNFFQKL
Physicochemical Analysis
C102H176N28O22
ARDCEHMPSTWYV
K
2146.69
11.29
7
0
6
+7
4.53
-0.911
86.67
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
2
Q
2
G
0
H
2
I
2
L
7
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 2 H: 0 I: 2 L: 2 K: 7 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C102H176N28O22
2146.69
11.29
+7
4.53
-0.911
Evidence Records 18 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.12 µM

Target

Escherichia coli KCTC 1682

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
CRAMP-18 E2K is active against E. coli KCTC 1682 (MIC 3.12 uM), S. typhimurium KCTC 1926 (MIC 1.56 uM), P. aeruginosa KCTC 1637 (MIC 0.78 uM), B. subtil
Evidence 2 Activity

Activity

MIC
Antibacterial
1.56 µM

Target

S. typhimurium KCTC 1926

Source & Reference

dbAMP

Other

CRAMP-18 E2K is active against E. coli KCTC 1682 (MIC 3.12 uM), S. typhimurium KCTC 1926 (MIC 1.56 uM), P. aeruginosa KCTC 1637 (MIC 0.78 uM), B. subtilis KCTC 1918 (MIC 3.12 uM), S. pyogenes
Evidence 3 Activity

Activity

MIC
Antibacterial
0.78 µM

Target

Pseudomonas aeruginosa KCTC 1637

Source & Reference

dbAMP

Other

s active against E. coli KCTC 1682 (MIC 3.12 uM), S. typhimurium KCTC 1926 (MIC 1.56 uM), P. aeruginosa KCTC 1637 (MIC 0.78 uM), B. subtilis KCTC 1918 (MIC 3.12 uM), S. pyogenes KCTC 3096 (MIC 3.12 uM), S. aureus KCTC
Evidence 4 Activity

Activity

MIC
Antibacterial
3.12 µM

Target

B. subtilis KCTC 1918

Source & Reference

dbAMP

Other

3.12 uM), S. typhimurium KCTC 1926 (MIC 1.56 uM), P. aeruginosa KCTC 1637 (MIC 0.78 uM), B. subtilis KCTC 1918 (MIC 3.12 uM), S. pyogenes KCTC 3096 (MIC 3.12 uM), S. aureus KCTC 1621 (MIC 1.56 uM), C. albicans (MIC
Evidence 5 Activity

Activity

MIC
Antibacterial
3.12 µM

Target

Streptococcus pyogenes KCTC 3096

Source & Reference

dbAMP

Other

MIC 1.56 uM), P. aeruginosa KCTC 1637 (MIC 0.78 uM), B. subtilis KCTC 1918 (MIC 3.12 uM), S. pyogenes KCTC 3096 (MIC 3.12 uM), S. aureus KCTC 1621 (MIC 1.56 uM), C. albicans (MIC 6.25 uM), A. fumigatus (MIC 12.5 uM)
Evidence 6 Activity

Activity

MIC
Antibacterial
1.56 µM

Target

Staphylococcus aureus KCTC 1621

Source & Reference

dbAMP

Other

(MIC 0.78 uM), B. subtilis KCTC 1918 (MIC 3.12 uM), S. pyogenes KCTC 3096 (MIC 3.12 uM), S. aureus KCTC 1621 (MIC 1.56 uM), C. albicans (MIC 6.25 uM), A. fumigatus (MIC 12.5 uM). Anticancer: tumor cells: A549 (IC
Evidence 7 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

18 (MIC 3.12 uM), S. pyogenes KCTC 3096 (MIC 3.12 uM), S. aureus KCTC 1621 (MIC 1.56 uM), C. albicans (MIC 6.25 uM), A. fumigatus (MIC 12.5 uM). Anticancer: tumor cells: A549 (IC50 25 uM), K562 (IC50 34 uM
Evidence 8 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

A. fumigatus

Source & Reference

dbAMP

Other

es KCTC 3096 (MIC 3.12 uM), S. aureus KCTC 1621 (MIC 1.56 uM), C. albicans (MIC 6.25 uM), A. fumigatus (MIC 12.5 uM). Anticancer: tumor cells: A549 (IC50 25 uM), K562 (IC50 34 uM), Jurkat (IC50 20 uM).
Evidence 9 Activity

Activity

MIC
Antifungal
3.12 µM

Target

Escherichia coli KCTC 1682

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
CRAMP-18 E2K is active against E. coli KCTC 1682 (MIC 3.12 uM), S. typhimurium KCTC 1926 (MIC 1.56 uM), P. aeruginosa KCTC 1637 (MIC 0.78 uM), B. subtil
Evidence 10 Activity

Activity

MIC
Antifungal
1.56 µM

Target

S. typhimurium KCTC 1926

Source & Reference

dbAMP CAFPdb Antifungipept

Other

CRAMP-18 E2K is active against E. coli KCTC 1682 (MIC 3.12 uM), S. typhimurium KCTC 1926 (MIC 1.56 uM), P. aeruginosa KCTC 1637 (MIC 0.78 uM), B. subtilis KCTC 1918 (MIC 3.12 uM), S. pyogenes
Evidence 11 Activity

Activity

MIC
Antifungal
0.78 µM

Target

Pseudomonas aeruginosa KCTC 1637

Source & Reference

dbAMP CAFPdb Antifungipept

Other

s active against E. coli KCTC 1682 (MIC 3.12 uM), S. typhimurium KCTC 1926 (MIC 1.56 uM), P. aeruginosa KCTC 1637 (MIC 0.78 uM), B. subtilis KCTC 1918 (MIC 3.12 uM), S. pyogenes KCTC 3096 (MIC 3.12 uM), S. aureus KCTC
Evidence 12 Activity

Activity

MIC
Antifungal
3.12 µM

Target

B. subtilis KCTC 1918

Source & Reference

dbAMP CAFPdb Antifungipept

Other

3.12 uM), S. typhimurium KCTC 1926 (MIC 1.56 uM), P. aeruginosa KCTC 1637 (MIC 0.78 uM), B. subtilis KCTC 1918 (MIC 3.12 uM), S. pyogenes KCTC 3096 (MIC 3.12 uM), S. aureus KCTC 1621 (MIC 1.56 uM), C. albicans (MIC
Evidence 13 Activity

Activity

MIC
Antifungal
3.12 µM

Target

Streptococcus pyogenes KCTC 3096

Source & Reference

dbAMP CAFPdb Antifungipept

Other

MIC 1.56 uM), P. aeruginosa KCTC 1637 (MIC 0.78 uM), B. subtilis KCTC 1918 (MIC 3.12 uM), S. pyogenes KCTC 3096 (MIC 3.12 uM), S. aureus KCTC 1621 (MIC 1.56 uM), C. albicans (MIC 6.25 uM), A. fumigatus (MIC 12.5 uM)
Evidence 14 Activity

Activity

MIC
Antifungal
1.56 µM

Target

Staphylococcus aureus KCTC 1621

Source & Reference

dbAMP CAFPdb Antifungipept

Other

(MIC 0.78 uM), B. subtilis KCTC 1918 (MIC 3.12 uM), S. pyogenes KCTC 3096 (MIC 3.12 uM), S. aureus KCTC 1621 (MIC 1.56 uM), C. albicans (MIC 6.25 uM), A. fumigatus (MIC 12.5 uM). Anticancer: tumor cells: A549 (IC
Evidence 15 Activity

Activity

MIC
Antifungal
6.25 µM

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

18 (MIC 3.12 uM), S. pyogenes KCTC 3096 (MIC 3.12 uM), S. aureus KCTC 1621 (MIC 1.56 uM), C. albicans (MIC 6.25 uM), A. fumigatus (MIC 12.5 uM). Anticancer: tumor cells: A549 (IC50 25 uM), K562 (IC50 34 uM
Evidence 16 Activity

Activity

MIC
Antifungal
12.5 µM

Target

A. fumigatus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

es KCTC 3096 (MIC 3.12 uM), S. aureus KCTC 1621 (MIC 1.56 uM), C. albicans (MIC 6.25 uM), A. fumigatus (MIC 12.5 uM). Anticancer: tumor cells: A549 (IC50 25 uM), K562 (IC50 34 uM), Jurkat (IC50 20 uM).
Evidence 17 Activity

Activity

0% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
0% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
CRAMP analogues having potent antibiotic activity against bacterial, fungal, and tumor cells without hemolytic activity | Biochem Biophys Res Commun | 2000
Evidence 18 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: Not active up to 100 µM | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem Biophys Res Commun. 2000 Sep 7 275(3):904-9.