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Peptide record

TPDB08683

Antibacterial Antifungal Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08683
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and Antifungipept, with an available 3D structural model.
Sequence
FLFSLIPSAIGGLISAFK
Physicochemical Analysis
C93H145N19O22
RNDCEQHMTWYV
ILFS
1881.29
10.10
1
0
11
+1
-4.49
1.567
141.11
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
3
I
3
L
1
K
0
M
3
F
1
P
3
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 3 K: 1 M: 0 F: 3 P: 1 S: 3 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C93H145N19O22
1881.29
10.10
+1
-4.49
1.567
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
7.5 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

NA

Other

Mainly active against Gram+ bacteria such as S. epidermidis ATCC 12228 (MIC 7.5 uM) and S. aureus (5 uM). and moderately active against Gram- E. coli ATCC 25922 (MIC 50 uM),
Evidence 2 Activity

Activity

MIC
Antibacterial
50 µM

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

ermidis ATCC 12228 (MIC 7.5 uM) and S. aureus (5 uM). and moderately active against Gram- E. coli ATCC 25922 (MIC 50 uM), S. enterica ATCC 10708 (60 uM), P. aeruginosa ATCC 27853 (40uM), A. baumannii ATCC 19606
Evidence 3 Activity

Activity

MIC
Antibacterial
20 µM

Target

A. baumannii ATCC 19606

Source & Reference

NA

Other

ATCC 25922 (MIC 50 uM), S. enterica ATCC 10708 (60 uM), P. aeruginosa ATCC 27853 (40uM), A. baumannii ATCC 19606 (MIC 20 uM), and K. pneumoniae (60 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
7.5 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

Antifungipept

Other

Mainly active against Gram+ bacteria such as S. epidermidis ATCC 12228 (MIC 7.5 uM) and S. aureus (5 uM). and moderately active against Gram- E. coli ATCC 25922 (MIC 50 uM),
Evidence 5 Activity

Activity

MIC
Antifungal
50 µM

Target

Escherichia coli ATCC 25922

Source & Reference

Antifungipept

Other

ermidis ATCC 12228 (MIC 7.5 uM) and S. aureus (5 uM). and moderately active against Gram- E. coli ATCC 25922 (MIC 50 uM), S. enterica ATCC 10708 (60 uM), P. aeruginosa ATCC 27853 (40uM), A. baumannii ATCC 19606
Evidence 6 Activity

Activity

MIC
Antifungal
20 µM

Target

A. baumannii ATCC 19606

Source & Reference

Antifungipept

Other

ATCC 25922 (MIC 50 uM), S. enterica ATCC 10708 (60 uM), P. aeruginosa ATCC 27853 (40uM), A. baumannii ATCC 19606 (MIC 20 uM), and K. pneumoniae (60 uM).
Evidence 7 Activity

Activity

0% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
0% Hemolysis | 40 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Peptide consensus sequence determination for the enhancement of the antimicrobial activity and selectivity of antimicrobial peptides. | Infect Drug Resist | 2016
Evidence 8 Activity

Activity

5% Hemolysis
Toxicity
60 µM
Hemolytic Cytotoxic
5% Hemolysis | 60 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Peptide consensus sequence determination for the enhancement of the antimicrobial activity and selectivity of antimicrobial peptides. | Infect Drug Resist | 2016
Evidence 9 Activity

Activity

22% Hemolysis
Toxicity
80 µM
Hemolytic Cytotoxic
22% Hemolysis | 80 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Peptide consensus sequence determination for the enhancement of the antimicrobial activity and selectivity of antimicrobial peptides. | Infect Drug Resist | 2016
Evidence 10 Activity

Activity

38% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
38% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Peptide consensus sequence determination for the enhancement of the antimicrobial activity and selectivity of antimicrobial peptides. | Infect Drug Resist | 2016