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Peptide record

TPDB08681

Antibacterial Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08681
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 18-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
WRNGRWWRNGRWWRNGRW
Physicochemical Analysis
C120H161N45O22
ADCEQHILKMFPSTYV
RW
2585.89
13.10
6
0
6
+6
-4.95
-2.450
0.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
33000
1276.16
3
Residue Composition
number
0
A
6
R
3
N
0
D
0
C
0
E
0
Q
3
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
6
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 3 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 6 Y: 0 V: 0
Chemical Descriptors
18
C120H161N45O22
2585.89
13.10
+6
-4.95
-2.450
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2-8 µM

Target

Escherichia coli ATCC 25922 or 1005

Source & Reference

NA

Other

active against E. coli ATCC 25922 or 1005 (MIC 2-8 uM), S. typhimurium 7731 (MIC 4 uM), S. aureus ATCC 29213 or 43300 MRSA (MIC 2-4 uM), B. subt
Evidence 2 Activity

Activity

MIC
Antibacterial
4 µM

Target

S. typhimurium 7731

Source & Reference

NA

Other

active against E. coli ATCC 25922 or 1005 (MIC 2-8 uM), S. typhimurium 7731 (MIC 4 uM), S. aureus ATCC 29213 or 43300 MRSA (MIC 2-4 uM), B. subtilis 63501 (MIC 4 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
2-4 µM

Target

Staphylococcus aureus ATCC 29213 or 43300 MRSA

Source & Reference

NA

Other

active against E. coli ATCC 25922 or 1005 (MIC 2-8 uM), S. typhimurium 7731 (MIC 4 uM), S. aureus ATCC 29213 or 43300 MRSA (MIC 2-4 uM), B. subtilis 63501 (MIC 4 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
4 µM

Target

B. subtilis 63501

Source & Reference

NA

Other

2-8 uM), S. typhimurium 7731 (MIC 4 uM), S. aureus ATCC 29213 or 43300 MRSA (MIC 2-4 uM), B. subtilis 63501 (MIC 4 uM).
Evidence 5 Activity

Activity

5% Hemolysis
Toxicity
>256 µM
Hemolytic Cytotoxic
5% Hemolysis | >256 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Short, multiple-stranded β-hairpin peptides have antimicrobial potency with high selectivity and salt resistance. | Acta Biomater | 2016