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Peptide record

TPDB08677

Antibacterial Antifungal Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08677
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and AFP-GFuse, with an available 3D structural model.
Sequence
GVCRCVCRRGVCRCVCRR
Physicochemical Analysis
C78H146N36O19S6
ANDEQHILKMFPSTWY
RC
2084.61
9.49
6
0
4
+6
3.72
0.222
64.44
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
375
17.99
6
Residue Composition
number
0
A
6
R
0
N
0
D
6
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
4
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 6 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 4
Chemical Descriptors
18
C78H146N36O19S6
2084.61
9.49
+6
3.72
0.222
Evidence Records 3 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1.56-12.5 µg/mL

Target

Candida albicans clinical isolates

Source & Reference

NA

Other

gainst E. coli ML35, S. aureus 502a, and C. albicans 16820. Active against drug resistant C. albicans clinical isolates (MIC 1.56-12.5 ug/ml) ( Basso et al., 2018 ).
Evidence 2 Activity

Activity

MIC
Antifungal
1.56-12.5 µg/mL

Target

Candida albicans clinical isolates

Source & Reference

NA

Other

gainst E. coli ML35, S. aureus 502a, and C. albicans 16820. Active against drug resistant C. albicans clinical isolates (MIC 1.56-12.5 ug/ml) ( Basso et al., 2018 ).
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The cyclic cystine ladder in ?-defensins is important for structure and stability, but not antibacterial activity. | J Biol Chem | 2013